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Catalog Number:
02382
CAS Number:
139090-50-9
Nα-Fmoc-Nω-(4-toluenesulfonyl)-D-arginine
Purity:
≥ 98% (HPLC)
Synonym(s):
Fmoc-D-Arg(Tos)-OH
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Product Information

Na-Fmoc-Nw-(4-toluenesulfonyl)-D-arginine is a versatile amino acid derivative widely utilized in peptide synthesis and drug development. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group, which facilitates the selective modification of the amino group, making it an essential building block in the synthesis of complex peptides. Its unique sulfonamide functionality enhances solubility and stability, allowing for efficient coupling reactions. Researchers in the fields of medicinal chemistry and biochemistry often employ this compound to create bioactive peptides, which can serve as potential therapeutics or research tools.

The compound's ability to form stable peptide bonds while maintaining the integrity of the arginine side chain makes it particularly valuable in the development of peptide-based drugs. Its application extends to the synthesis of peptide inhibitors, which can target specific biological pathways, offering promising avenues for therapeutic intervention. With its favorable properties and ease of use, Na-Fmoc-Nw-(4-toluenesulfonyl)-D-arginine stands out as a preferred choice for professionals seeking reliable and efficient solutions in peptide chemistry.

Synonyms
Fmoc-D-Arg(Tos)-OH
CAS Number
139090-50-9
Purity
≥ 98% (HPLC)
Molecular Formula
C28H30N4O6S
Molecular Weight
550.6
MDL Number
MFCD00065621
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +5.2 ± 0.5º (C=2 in DMF)
Conditions
Store at 0-8°C
General Information
Synonyms
Fmoc-D-Arg(Tos)-OH
CAS Number
139090-50-9
Purity
≥ 98% (HPLC)
Molecular Formula
C28H30N4O6S
Molecular Weight
550.6
MDL Number
MFCD00065621
Appearance
White to off-white powder
Optical Rotation
[a]D20 = +5.2 ± 0.5º (C=2 in DMF)
Conditions
Store at 0-8°C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Na-Fmoc-Nw-(4-toluenesulfonyl)-D-arginine is widely utilized in research focused on:

  • Peptide Synthesis: This compound is a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing researchers to create complex peptide sequences efficiently.
  • Drug Development: It plays a significant role in the pharmaceutical industry for developing peptide-based drugs, offering potential therapeutic benefits in treating various diseases.
  • Bioconjugation: The chemical is used in bioconjugation processes, enabling the attachment of peptides to other biomolecules, which is crucial for creating targeted drug delivery systems.
  • Research in Biochemistry: It is valuable in biochemistry research for studying protein interactions and functions, aiding in the understanding of cellular processes.
  • Diagnostic Applications: The compound can be utilized in the development of diagnostic tools, particularly in assays that require specific peptide interactions, enhancing the accuracy of disease detection.

Citations