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Catalog Number:
03620
CAS Number:
125043-04-1
Fmoc-D-alanine pentafluorophenyl ester
Purity:
≥ 97% (HPLC)
Synonym(s):
Fmoc-D-Ala-OPfp
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Product Information

Fmoc-D-alanine pentafluorophenyl ester is a highly versatile compound widely utilized in peptide synthesis and drug development. This compound serves as a valuable building block for the preparation of peptides, particularly in solid-phase peptide synthesis (SPPS), due to its stability and ease of handling. The presence of the Fmoc (fluorenylmethyloxycarbonyl) protecting group allows for selective deprotection under mild conditions, making it an ideal choice for researchers aiming to construct complex peptide sequences efficiently. Its pentafluorophenyl ester moiety enhances the reactivity and solubility of the compound, facilitating smoother reactions and higher yields in synthetic processes.

In addition to its applications in peptide synthesis, Fmoc-D-alanine pentafluorophenyl ester is also relevant in the development of pharmaceuticals and biologically active compounds. Its unique properties allow for the incorporation of D-amino acids into peptides, which can significantly influence the biological activity and stability of the resulting molecules. This compound is particularly beneficial for researchers focused on designing peptides with enhanced therapeutic potential, making it a crucial tool in the fields of medicinal chemistry and biochemistry.

Synonyms
Fmoc-D-Ala-OPfp
CAS Number
125043-04-1
Purity
≥ 97% (HPLC)
Molecular Formula
C24H16F5NO4
Molecular Weight
477.4
MDL Number
MFCD00153372
PubChem ID
4340367
Melting Point
173-179 °C
Appearance
White powder
Optical Rotation
[α]D = +20 ± 2º (C=1 in CHCl3)
Conditions
Store at 0-8 °C
General Information
Synonyms
Fmoc-D-Ala-OPfp
CAS Number
125043-04-1
Purity
≥ 97% (HPLC)
Molecular Formula
C24H16F5NO4
Molecular Weight
477.4
MDL Number
MFCD00153372
PubChem ID
4340367
Melting Point
173-179 °C
Appearance
White powder
Optical Rotation
[α]D = +20 ± 2º (C=1 in CHCl3)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fmoc-D-alanine pentafluorophenyl ester is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, enabling researchers to create complex molecules for drug development and biological studies.
  • Protein Engineering: Its unique structure allows for the selective modification of amino acids in proteins, facilitating the design of proteins with enhanced stability and functionality.
  • Drug Discovery: By using this ester in high-throughput screening, pharmaceutical companies can identify potential drug candidates more efficiently, speeding up the development process.
  • Bioconjugation: The pentafluorophenyl group provides excellent reactivity for bioconjugation applications, allowing for the attachment of various biomolecules, which is crucial in creating targeted therapies.
  • Analytical Chemistry: It is utilized in analytical methods for the detection and quantification of peptides, aiding researchers in characterizing new compounds and understanding their properties.

Citations