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Catalog Number:
00931
CAS Number:
30516-87-1
3'-Azido-3'-deoxythymidine
Grade:
Meets USP specification
Purity:
97 - 102% (Assay : Anhydrous basis)
Synonym(s):
AZT, Azidothymidine
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Product Information

3'-Azido-3'-deoxythymidine, commonly known as AZT, is a crucial nucleoside analog with significant applications in antiviral therapies, particularly in the treatment of HIV/AIDS. This compound functions by inhibiting the reverse transcriptase enzyme, which is essential for viral replication, thereby reducing the viral load in patients. Its unique azido group enhances its efficacy, making it a vital component in combination antiretroviral therapy. Researchers and pharmaceutical professionals value 3'-Azido-3'-deoxythymidine for its ability to penetrate cellular membranes effectively, ensuring optimal bioavailability and therapeutic action.

In addition to its primary use in HIV treatment, 3'-Azido-3'-deoxythymidine is also being explored for potential applications in cancer research and other viral infections. Its structural properties allow for modifications that can lead to the development of new derivatives with enhanced activity and reduced side effects. The compound's established safety profile and extensive research background make it a reliable choice for both clinical and laboratory settings, providing researchers with a powerful tool in the fight against viral diseases.

Synonyms
AZT, Azidothymidine
CAS Number
30516-87-1
Purity
97 - 102% (Assay : Anhydrous basis)
Grade
Meets USP specification
Molecular Formula
C10H13N5O4
Molecular Weight
267.25
MDL Number
MFCD00006536
PubChem ID
5726
Melting Point
121 - 125 °C
Appearance
White to yellowish powder
Optical Rotation
[a]20D = 60.5 - 63.0 º (C=10 mg/mL in Alcohol)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
AZT, Azidothymidine
CAS Number
30516-87-1
Purity
97 - 102% (Assay : Anhydrous basis)
Grade
Meets USP specification
Molecular Formula
C10H13N5O4
Molecular Weight
267.25
MDL Number
MFCD00006536
PubChem ID
5726
Melting Point
121 - 125 °C
Appearance
White to yellowish powder
Optical Rotation
[a]20D = 60.5 - 63.0 º (C=10 mg/mL in Alcohol)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

3'-Azido-3'-deoxythymidine is widely utilized in research focused on

  • Antiviral Treatments: This compound is a key ingredient in the development of antiviral medications, particularly for HIV. It works by inhibiting viral replication, making it essential in antiretroviral therapy.
  • Research in Molecular Biology: It serves as a valuable tool in molecular biology for studying DNA synthesis and repair mechanisms. Researchers use it to explore the effects of nucleoside analogs on cellular processes.
  • Drug Development: Pharmaceutical companies leverage this compound in the design of new drugs. Its unique structure allows for modifications that can enhance efficacy and reduce side effects compared to traditional therapies.
  • Diagnostic Applications: In diagnostics, it is used in assays to detect viral infections. Its ability to incorporate into viral DNA makes it useful for developing sensitive detection methods.
  • Gene Therapy: The compound is being explored in gene therapy applications, where it can be used to deliver genetic material into cells, offering potential treatments for genetic disorders.

Citations