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Catalog Number:
29691
CAS Number:
1242934-32-2
2S,4S-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid
Purity:
≥ 98% (HPLC)
Documents
$127.79 /25MG
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Product Information

The compound (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid is a highly valuable building block in peptide synthesis and medicinal chemistry. Known for its unique trifluoromethyl group, this compound enhances the lipophilicity and metabolic stability of peptides, making it an essential component in the development of pharmaceuticals. Its Fmoc (9-fluorenylmethoxycarbonyl) protecting group allows for easy incorporation into peptide chains while providing excellent stability during synthesis.

Researchers and industry professionals utilize this compound in the design of bioactive peptides, particularly in drug discovery processes targeting various diseases. The trifluoromethyl moiety not only contributes to the compound's biological activity but also improves the overall pharmacokinetic profile of the resulting peptides. Its application extends to the synthesis of peptide-based therapeutics, where enhanced potency and selectivity are crucial. This compound stands out for its ability to facilitate the creation of complex peptide structures that are vital in modern medicinal chemistry.

CAS Number
1242934-32-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H18F3NO4
Molecular Weight
405.37
MDL Number
MFCD11226824
PubChem ID
75110602
Appearance
White powder
Optical Rotation
[a]D20 = -39 ± 2º (C=1 in MeOH) or [a]D20 = -51 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
General Information
CAS Number
1242934-32-2
Purity
≥ 98% (HPLC)
Molecular Formula
C21H18F3NO4
Molecular Weight
405.37
MDL Number
MFCD11226824
PubChem ID
75110602
Appearance
White powder
Optical Rotation
[a]D20 = -39 ± 2º (C=1 in MeOH) or [a]D20 = -51 ± 2º (C=1 in DMF)
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, enhancing the efficiency and yield of the process.
  • Drug Development: Its unique trifluoromethyl group can improve the pharmacological properties of drug candidates, making it valuable in medicinal chemistry for developing more effective therapeutics.
  • Bioconjugation: The compound is used in bioconjugation strategies, allowing researchers to attach biomolecules to surfaces or other molecules, which is crucial in developing targeted drug delivery systems.
  • Research on Fluorinated Compounds: It provides insights into the behavior of fluorinated compounds in biological systems, aiding researchers in understanding the effects of fluorination on molecular interactions.
  • Analytical Chemistry: This chemical is employed in analytical techniques to improve the sensitivity and selectivity of assays, particularly in the detection of biomolecules.

Citations