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Catalog Number:
15585
CAS Number:
501015-19-6
(R)-Boc-4-(trifluoromethyl)-b-Phe-OH
Purity:
≥ 99.5% (Chiral HPLC)
Synonym(s):
Boc-D-β-Phe(4-CF3)-OH, Boc-(R)-3-amino-3-(4 trifluoromethylphenyl)propionic acid
Documents
$30.00 /100MG
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Product Information

(R)-Boc-4-(trifluoromethyl)-ß-Phe-OH is a specialized amino acid derivative that plays a crucial role in pharmaceutical and biochemical research. This compound, known for its unique trifluoromethyl group, enhances the lipophilicity and metabolic stability of peptides and proteins, making it an invaluable tool in drug design and development. Its Boc (tert-butyloxycarbonyl) protecting group allows for selective deprotection, facilitating the synthesis of complex peptide structures. Researchers utilize this compound in the development of novel therapeutics, particularly in the fields of oncology and neurology, where precise modifications can lead to improved drug efficacy and reduced side effects.

The compound's distinct properties make it particularly advantageous for creating peptide-based drugs with enhanced bioavailability. Its application in solid-phase peptide synthesis (SPPS) allows for efficient assembly of peptides, streamlining the production process. Additionally, the trifluoromethyl group contributes to the compound's unique electronic properties, which can be leveraged to optimize interactions with biological targets. Overall, (R)-Boc-4-(trifluoromethyl)-ß-Phe-OH stands out as a versatile building block for researchers aiming to innovate in peptide chemistry and drug development.

Synonyms
Boc-D-β-Phe(4-CF3)-OH, Boc-(R)-3-amino-3-(4 trifluoromethylphenyl)propionic acid
CAS Number
501015-19-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C15H18F3NO4
Molecular Weight
333.31
MDL Number
MFCD03427965
PubChem ID
2766034
Melting Point
150 - 157 ?C
Appearance
White powder
Optical Rotation
[a]D20 = 30 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-D-β-Phe(4-CF3)-OH, Boc-(R)-3-amino-3-(4 trifluoromethylphenyl)propionic acid
CAS Number
501015-19-6
Purity
≥ 99.5% (Chiral HPLC)
Molecular Formula
C15H18F3NO4
Molecular Weight
333.31
MDL Number
MFCD03427965
PubChem ID
2766034
Melting Point
150 - 157 ?C
Appearance
White powder
Optical Rotation
[a]D20 = 30 ± 1 º (C=1 in DMF)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(R)-Boc-4-(trifluoromethyl)-ß-Phe-OH is widely utilized in research focused on

  • Pharmaceutical Development: This compound serves as an important intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting neurological disorders.
  • Peptide Synthesis: It is commonly used in solid-phase peptide synthesis, allowing researchers to create complex peptides with enhanced stability and bioactivity.
  • Research in Medicinal Chemistry: The unique trifluoromethyl group enhances the lipophilicity of compounds, making it valuable in the design of new drug candidates that require improved membrane permeability.
  • Bioconjugation Applications: This chemical can be utilized in bioconjugation processes, facilitating the attachment of biomolecules to therapeutic agents, which is crucial for targeted drug delivery systems.
  • Material Science: Its properties are leveraged in the development of novel materials, particularly in creating polymers with specific functionalities for use in coatings and adhesives.

Citations