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Catalog Number:
38306
CAS Number:
133550-30-8
Tyrphostin AG 490
Purity:
≥ 98% (HPLC)
Synonym(s):
(E-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide
Hazmat
Documents
$75.11 /20MG
Pack Size Availability Price
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Product Information

Tyrphostin AG 490 is a potent and selective inhibitor of the Janus kinase (JAK) family, particularly JAK2, making it a valuable tool in both research and therapeutic applications. This compound is recognized for its ability to modulate signaling pathways involved in cell proliferation and differentiation, particularly in hematopoietic cells. Researchers utilize Tyrphostin AG 490 to investigate the roles of JAKs in various biological processes, including immune responses and cancer progression. Its unique structure, featuring a cyano and a dihydroxyphenyl group, enhances its binding affinity and specificity, setting it apart from other kinase inhibitors.

In practical applications, Tyrphostin AG 490 has shown promise in studies related to autoimmune diseases and hematological malignancies, providing insights into potential therapeutic strategies. Its ability to inhibit JAK2 activity is particularly relevant in the context of diseases where aberrant JAK signaling is implicated. By incorporating Tyrphostin AG 490 into experimental designs, researchers can explore innovative approaches to target JAK-mediated pathways, ultimately contributing to the development of novel treatments.

Synonyms
(E-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide
CAS Number
133550-30-8
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14N2O3
Molecular Weight
294.31
MDL Number
MFCD00236452
PubChem ID
2390
Melting Point
214 - 216 °C
Appearance
White to pale yellow powder or crystals
Conditions
Store at < 0 °C
General Information
Synonyms
(E-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide
CAS Number
133550-30-8
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14N2O3
Molecular Weight
294.31
MDL Number
MFCD00236452
PubChem ID
2390
Melting Point
214 - 216 °C
Appearance
White to pale yellow powder or crystals
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tyrphostin AG 490 is widely utilized in research focused on:

  • Cancer Research: This compound acts as a potent inhibitor of specific tyrosine kinases, making it valuable for studying cancer cell signaling pathways and potential therapeutic targets.
  • Neuroscience: It has applications in neurobiological studies, particularly in understanding the role of growth factors in neuronal survival and differentiation.
  • Diabetes Research: Tyrphostin AG 490 is used to investigate insulin signaling pathways, helping researchers explore new treatments for insulin resistance and diabetes.
  • Inflammation Studies: The compound is effective in examining the mechanisms of inflammation, providing insights into chronic inflammatory diseases and potential interventions.
  • Drug Development: Its ability to modulate kinase activity makes it a useful tool in the development of new drugs aimed at various diseases, including those related to cell growth and proliferation.

Citations