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Catalog Number:
02883
CAS Number:
76-05-1
Trifluoroacetic acid
Purity:
≥ 99.9% (Assay)
Synonym(s):
TFA
Hazmat
Documents
$30.00 /25G
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Product Information

Trifluoroacetic acid is a highly versatile compound widely utilized in various industrial and research applications due to its unique properties. This colorless liquid, characterized by its strong acidity and high polarity, serves as an effective reagent in organic synthesis, particularly in the production of fluorinated compounds. Its ability to act as a solvent and catalyst makes it invaluable in peptide synthesis and the pharmaceutical industry, where it is employed to enhance the solubility of compounds and facilitate reactions. Additionally, trifluoroacetic acid is commonly used in analytical chemistry for the derivatization of amino acids and other biomolecules, allowing for improved detection and quantification in chromatographic techniques.

Researchers and industry professionals appreciate trifluoroacetic acid for its ability to stabilize reactive intermediates and its compatibility with a wide range of substrates. Its unique trifluoromethyl group imparts distinct electronic properties, making it a preferred choice for synthesizing complex molecules in medicinal chemistry. The compound's effectiveness in modifying polymer surfaces and its role in the production of agrochemicals further highlight its significance across diverse fields. With its robust performance and broad applicability, trifluoroacetic acid remains an essential tool for advancing chemical research and industrial processes.

Synonyms
TFA
CAS Number
76-05-1
Purity
≥ 99.9% (Assay)
Molecular Formula
C2HF3O2
Molecular Weight
114.02
MDL Number
MFCD00004169
PubChem ID
6422
Melting Point
-15 ?C
Density
1.485
Appearance
Colorless liquid
Boiling Point
72 ?C
Conditions
Store at RT
General Information
Synonyms
TFA
CAS Number
76-05-1
Purity
≥ 99.9% (Assay)
Molecular Formula
C2HF3O2
Molecular Weight
114.02
MDL Number
MFCD00004169
PubChem ID
6422
Melting Point
-15 ?C
Density
1.485
Appearance
Colorless liquid
Boiling Point
72 ?C
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Trifluoroacetic acid is widely utilized in research focused on:

  • Organic Synthesis: It serves as a powerful reagent in the synthesis of various organic compounds, enhancing reaction efficiency and selectivity.
  • Peptide Chemistry: Commonly used in peptide synthesis, it helps in the deprotection of amino acids, facilitating the creation of complex peptide structures.
  • Analytical Chemistry: Acts as a solvent and acidifying agent in chromatography, improving the separation and analysis of compounds in various samples.
  • Pharmaceutical Development: Plays a role in drug formulation and modification, particularly in enhancing the solubility and stability of active pharmaceutical ingredients.
  • Environmental Studies: Utilized in the analysis of environmental samples, aiding in the detection and quantification of pollutants due to its strong acidity and reactivity.

Citations