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Catalog Number:
00614
CAS Number:
18162-48-6
tert-Butyldimethylsilyl chloride
Purity:
≥ 99% (GC)
Synonym(s):
tert-Butyldimethylchlorosilane, TBDMSCL
Hazmat
Documents
$19.60 /25G
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Product Information

tert-Butyldimethylsilyl chloride is a versatile reagent widely utilized in organic synthesis and chemical research. This compound serves as a protective group for alcohols and amines, allowing chemists to selectively modify other functional groups without interference. Its unique structure enables the formation of stable silyl ethers, which are crucial in various synthetic pathways, particularly in the synthesis of complex organic molecules. Researchers appreciate its efficiency in facilitating reactions while maintaining high yields, making it an essential tool in laboratories focused on organic chemistry.

In addition to its protective capabilities, tert-Butyldimethylsilyl chloride is also employed in the preparation of silyl derivatives, which are valuable in the development of pharmaceuticals and agrochemicals. Its ability to enhance the stability and solubility of compounds makes it particularly beneficial in drug formulation processes. With its broad applicability and effectiveness, this compound stands out as a preferred choice for professionals seeking reliable and efficient solutions in their synthetic endeavors.

Synonyms
tert-Butyldimethylchlorosilane, TBDMSCL
CAS Number
18162-48-6
Purity
≥ 99% (GC)
Molecular Formula
C6H15ClSi
Molecular Weight
150.7
MDL Number
MFCD00000501
PubChem ID
28928
Melting Point
86-89?C
Appearance
White crystal
Boiling Point
124-126?C @ 760mmHg
Conditions
Store at 0-8 °C
General Information
Synonyms
tert-Butyldimethylchlorosilane, TBDMSCL
CAS Number
18162-48-6
Purity
≥ 99% (GC)
Molecular Formula
C6H15ClSi
Molecular Weight
150.7
MDL Number
MFCD00000501
PubChem ID
28928
Melting Point
86-89?C
Appearance
White crystal
Boiling Point
124-126?C @ 760mmHg
Conditions
Store at 0-8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

tert-Butyldimethylsilyl chloride is widely utilized in research focused on:

  • Protective Group in Organic Synthesis: It serves as a protective group for alcohols and amines, allowing chemists to selectively modify other functional groups without interference. This is crucial in multi-step synthesis where specific reactions need to be controlled.
  • Silicon-Based Materials: The compound is used in the preparation of silicon-containing compounds, which are important in the development of advanced materials like silicones and hybrid polymers, enhancing their thermal stability and mechanical properties.
  • Pharmaceutical Development: In the pharmaceutical industry, it aids in the synthesis of complex organic molecules, improving the efficiency of drug development processes by facilitating the creation of diverse chemical libraries.
  • Surface Modification: It is applied in modifying surfaces of materials to improve their hydrophobicity and chemical resistance, which is beneficial in coatings and sealants used in various industrial applications.
  • Analytical Chemistry: The compound is used in sample preparation techniques, enhancing the sensitivity and selectivity of analytical methods such as gas chromatography, which is essential for accurate chemical analysis.

Citations