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Catalog Number:
02591
CAS Number:
52-67-5
D-Penicillamine
Grade:
USP
Purity:
98 - 101% (Assay on dried basis)
Synonym(s):
D-Pen-OH, D-2-Amino-3-mercapto-3-methylbutanoic acid, H-D-Pen-OH
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Product Information

D-Penicillamine is a versatile thiol compound renowned for its applications in both pharmaceuticals and industrial processes. This amino acid derivative is primarily utilized in the treatment of conditions such as rheumatoid arthritis and Wilson's disease, where it acts as a chelating agent, effectively binding to heavy metals and facilitating their excretion from the body. Its unique ability to form stable complexes with metals makes it invaluable in clinical settings, providing relief to patients by reducing metal toxicity and alleviating symptoms associated with these diseases.

In addition to its medicinal uses, D-Penicillamine is also employed in various industrial applications, including the manufacturing of specialized polymers and as a reagent in analytical chemistry. Its properties as a reducing agent and its role in the synthesis of other chemical compounds further enhance its utility in research and development. With its dual functionality in both healthcare and industry, D-Penicillamine stands out as a compound of significant relevance, offering practical solutions to complex challenges faced by professionals in these fields.

Synonyms
D-Pen-OH, D-2-Amino-3-mercapto-3-methylbutanoic acid, H-D-Pen-OH
CAS Number
52-67-5
Purity
98 - 101% (Assay on dried basis)
Grade
USP
Molecular Formula
C5H11NO2S
Molecular Weight
149.2
MDL Number
MFCD00064302
PubChem ID
4727
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D20 = -60.5 to -64.5 ° (C=1 in 1N NaOH)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
D-Pen-OH, D-2-Amino-3-mercapto-3-methylbutanoic acid, H-D-Pen-OH
CAS Number
52-67-5
Purity
98 - 101% (Assay on dried basis)
Grade
USP
Molecular Formula
C5H11NO2S
Molecular Weight
149.2
MDL Number
MFCD00064302
PubChem ID
4727
Appearance
White to off-white crystalline powder
Optical Rotation
[a]D20 = -60.5 to -64.5 ° (C=1 in 1N NaOH)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

D-Penicillamine is widely utilized in research focused on

  • Rheumatoid Arthritis Treatment: It serves as a disease-modifying antirheumatic drug (DMARD), helping to reduce inflammation and slow disease progression in patients.
  • Copper Overload Disorders: Effective in treating Wilson's disease, D-Penicillamine aids in the excretion of excess copper, preventing organ damage.
  • Heavy Metal Detoxification: It acts as a chelating agent, binding to heavy metals like lead and mercury, facilitating their removal from the body.
  • Kidney Stone Prevention: D-Penicillamine can help dissolve cystine stones, providing a non-surgical option for patients suffering from cystinuria.
  • Research in Biochemistry: It is used in studies investigating protein interactions and enzyme functions due to its unique thiol group, which can modify protein structures.

Citations