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Catalog Number:
38239
CAS Number:
162011-90-7
Rofecoxib
Purity:
≥ 98% (GC)
Synonym(s):
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Documents
$124.99 /250MG
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Product Information

Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily recognized for its anti-inflammatory and analgesic properties. This compound is widely utilized in the pharmaceutical industry for the management of pain and inflammation associated with conditions such as arthritis and acute pain episodes. Its unique mechanism of action allows for effective pain relief while minimizing gastrointestinal side effects commonly associated with non-steroidal anti-inflammatory drugs (NSAIDs). Rofecoxib's efficacy in reducing inflammation makes it a valuable option for researchers exploring new therapeutic pathways in pain management and inflammatory diseases.

In addition to its clinical applications, Rofecoxib has been the subject of extensive research, highlighting its potential in various therapeutic areas, including cardiovascular health and cancer treatment. Its ability to selectively inhibit COX-2 without affecting COX-1 provides a significant advantage over traditional NSAIDs, making it a preferred choice in specific patient populations. With ongoing studies and interest in its applications, Rofecoxib continues to hold promise for future developments in pain management and inflammatory disease treatment.

Synonyms
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
CAS Number
162011-90-7
Purity
≥ 98% (GC)
Molecular Formula
C17H14O4S
Molecular Weight
314.36
MDL Number
MFCD00935806
PubChem ID
5090
Melting Point
207 - 211 °C
Appearance
White to yellow to orange powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
CAS Number
162011-90-7
Purity
≥ 98% (GC)
Molecular Formula
C17H14O4S
Molecular Weight
314.36
MDL Number
MFCD00935806
PubChem ID
5090
Melting Point
207 - 211 °C
Appearance
White to yellow to orange powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Rofecoxib is widely utilized in research focused on:

  • Pain Management: Commonly used in clinical settings for its effectiveness in alleviating pain, particularly in conditions like arthritis. Its selective inhibition of COX-2 enzymes helps reduce inflammation with fewer gastrointestinal side effects compared to traditional NSAIDs.
  • Cardiovascular Research: Investigated for its potential impact on cardiovascular health, Rofecoxib has been studied for its role in managing pain without significantly increasing cardiovascular risks, making it a subject of interest for heart disease research.
  • Pharmaceutical Development: Used as a reference compound in the development of new analgesics and anti-inflammatory drugs, helping researchers understand the mechanisms of action and improve drug efficacy.
  • Veterinary Medicine: Applied in veterinary practices to manage pain and inflammation in animals, showcasing its versatility beyond human medicine and providing relief in various species.
  • Clinical Trials: Frequently featured in clinical trials aimed at evaluating new treatment protocols for chronic pain conditions, offering insights into patient responses and long-term outcomes.

Citations