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Catalog Number:
38189
CAS Number:
137281-23-3
Pemetrexed
Purity:
≥ 98% (HPLC)
Synonym(s):
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid
Documents
$84.83 /250MG
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Product Information

Pemetrexed is a versatile antifolate compound primarily used in the treatment of various cancers, including non-small cell lung cancer and mesothelioma. This multi-targeted agent works by inhibiting key enzymes involved in folate metabolism, which is crucial for DNA synthesis and cell division. Its unique mechanism of action allows it to disrupt the growth of cancer cells effectively, making it a valuable option in chemotherapy regimens. Pemetrexed is often utilized in combination with other chemotherapeutic agents to enhance therapeutic efficacy and improve patient outcomes.

In addition to its oncological applications, Pemetrexed has shown promise in research settings, particularly in studies exploring its effects on tumor microenvironments and resistance mechanisms. Researchers appreciate its ability to provide insights into cancer biology and treatment resistance, making it a significant compound in both clinical and laboratory settings. With its proven track record and ongoing research, Pemetrexed continues to be an essential tool for healthcare professionals and researchers alike.

Synonyms
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid
CAS Number
137281-23-3
Purity
≥ 98% (HPLC)
Molecular Formula
C20H21N5O6
Molecular Weight
427.42
MDL Number
MFCD19105065
PubChem ID
135469568
Appearance
White to blue powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid
CAS Number
137281-23-3
Purity
≥ 98% (HPLC)
Molecular Formula
C20H21N5O6
Molecular Weight
427.42
MDL Number
MFCD19105065
PubChem ID
135469568
Appearance
White to blue powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Pemetrexed is widely utilized in research focused on

  • Cancer Treatment: Primarily used as a chemotherapy agent for treating non-small cell lung cancer and mesothelioma, it helps inhibit cancer cell growth by interfering with folate metabolism.
  • Combination Therapy: Often combined with other drugs to enhance efficacy, pemetrexed can improve patient outcomes when used alongside platinum-based therapies, making it a versatile option in oncology.
  • Research in Drug Resistance: It is a valuable compound for studying mechanisms of drug resistance in cancer cells, helping researchers develop strategies to overcome therapeutic challenges.
  • Biomarker Development: Pemetrexed is used in clinical studies to identify biomarkers that predict patient response, aiding in personalized medicine approaches for more effective treatment plans.
  • Pharmaceutical Formulation: Its properties allow for various formulations, including intravenous and oral delivery, providing flexibility in treatment administration based on patient needs.

Citations