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Catalog Number:
38009
CAS Number:
130018-87-0
Levocetirizine dihydrochloride
Purity:
98 - 102% (Assay on dried basis)
Synonym(s):
2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]aceticacid dihydrochloride
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Product Information

Levocetirizine dihydrochloride is a potent antihistamine known for its effectiveness in alleviating allergic symptoms such as rhinitis and urticaria. This compound, a refined enantiomer of cetirizine, offers enhanced therapeutic benefits with a reduced sedative effect, making it an ideal choice for patients seeking relief without the drowsiness commonly associated with other antihistamines. Its unique molecular structure allows for better receptor binding, which translates to improved efficacy in managing allergic reactions.

In clinical settings, Levocetirizine dihydrochloride is widely utilized in the treatment of seasonal and perennial allergic rhinitis, as well as chronic idiopathic urticaria. Its rapid onset of action and long duration of effect make it a preferred option for both healthcare providers and patients. Additionally, its favorable safety profile allows for use in a broad patient population, including children and the elderly. Researchers and industry professionals appreciate its versatility and effectiveness, positioning Levocetirizine dihydrochloride as a leading choice in allergy management.

Synonyms
2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]aceticacid dihydrochloride
CAS Number
130018-87-0
Purity
98 - 102% (Assay on dried basis)
Molecular Formula
C21H25ClN2O3·2HCl
Molecular Weight
461.81
MDL Number
MFCD07366507
PubChem ID
55182
Melting Point
213 - 215 °C (Lit.)
Appearance
A white or almost white powder
Optical Rotation
[a]D20 = 10 - 14 ° (C=1% in water) (On dried basis)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]aceticacid dihydrochloride
CAS Number
130018-87-0
Purity
98 - 102% (Assay on dried basis)
Molecular Formula
C21H25ClN2O3·2HCl
Molecular Weight
461.81
MDL Number
MFCD07366507
PubChem ID
55182
Melting Point
213 - 215 °C (Lit.)
Appearance
A white or almost white powder
Optical Rotation
[a]D20 = 10 - 14 ° (C=1% in water) (On dried basis)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Levocetirizine dihydrochloride is widely utilized in research focused on:

  • Allergy Relief: Commonly used in the pharmaceutical industry, it effectively alleviates symptoms of allergic rhinitis and chronic urticaria, providing relief for patients suffering from seasonal allergies.
  • Clinical Trials: Frequently involved in clinical studies to assess its efficacy and safety, helping researchers gather data on its effects compared to other antihistamines.
  • Formulation Development: Utilized in the development of various dosage forms, such as tablets and syrups, allowing for flexible administration options tailored to patient needs.
  • Pediatric Applications: Its favorable safety profile makes it suitable for use in children, addressing the specific challenges of treating allergic conditions in younger populations.
  • Research on Antihistamine Mechanisms: Employed in academic research to explore the pharmacological mechanisms of antihistamines, contributing to the understanding of allergy treatments and potential new therapies.

Citations