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Catalog Number:
37734
CAS Number:
169590-42-5
Celecoxib
Grade:
USP
Purity:
98 - 102% (Assay on anhydrous basis)
Synonym(s):
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, 5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole
Documents
$18.50 /200MG
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Product Information

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) widely recognized for its selective inhibition of cyclooxygenase-2 (COX-2), making it a valuable option for managing pain and inflammation. This compound is particularly effective in treating conditions such as osteoarthritis, rheumatoid arthritis, and acute pain, providing relief while minimizing gastrointestinal side effects commonly associated with traditional NSAIDs. Celecoxib's unique structure, featuring a trifluoromethyl group, enhances its potency and selectivity, making it a preferred choice in both clinical and research settings.

In addition to its therapeutic applications, Celecoxib is also being explored for its potential in cancer treatment, particularly in reducing tumor growth and metastasis in certain types of cancers. Its ability to modulate inflammatory pathways positions it as a promising candidate for further research in oncology. With its established efficacy and ongoing research into new applications, Celecoxib remains a critical compound for healthcare professionals and researchers seeking effective solutions for pain management and inflammation control.

Synonyms
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, 5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole
CAS Number
169590-42-5
Purity
98 - 102% (Assay on anhydrous basis)
Grade
USP
Molecular Formula
C17H14F3N3O2S
Molecular Weight
381.37
MDL Number
MFCD00941298
PubChem ID
2662
Melting Point
161 - 165 °C
Appearance
White to off-white crystalline powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, 5-(4-Methylphenyl)-1-(4-sulfamoylphenyl)-3-(trifluoromethyl)pyrazole
CAS Number
169590-42-5
Purity
98 - 102% (Assay on anhydrous basis)
Grade
USP
Molecular Formula
C17H14F3N3O2S
Molecular Weight
381.37
MDL Number
MFCD00941298
PubChem ID
2662
Melting Point
161 - 165 °C
Appearance
White to off-white crystalline powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Celecoxib is widely utilized in research focused on:

  • Pain Management: Commonly prescribed for conditions like arthritis, Celecoxib effectively reduces inflammation and pain, providing relief for patients suffering from chronic pain conditions.
  • Cardiovascular Research: Its selective inhibition of COX-2 makes it a key compound in studies exploring the cardiovascular effects of non-steroidal anti-inflammatory drugs (NSAIDs), helping researchers understand safer pain relief options.
  • Cancer Treatment Studies: Celecoxib is being investigated for its potential role in cancer therapy, particularly in colorectal cancer, due to its ability to inhibit tumor growth and promote apoptosis in cancer cells.
  • Postoperative Pain Relief: In surgical settings, Celecoxib is used to manage postoperative pain, offering an alternative to traditional opioids, which can reduce the risk of dependency and side effects.
  • Research on Gastrointestinal Safety: Compared to other NSAIDs, Celecoxib is associated with a lower risk of gastrointestinal complications, making it a valuable subject in studies aimed at improving patient safety in pain management.

Citations