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Catalog Number:
41986
CAS Number:
3520-43-2
JC-1
Grade:
suitable for Hematology & Histology
Purity:
≥ 97% (HPLC)
Synonym(s):
5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanineiodide, 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanineiodide, CBIC2(3)
Documents
$616.62 /5MG
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Product Information

JC-1 is a potent fluorescent dye widely utilized in biological research, particularly in the study of mitochondrial membrane potential. This compound exhibits remarkable sensitivity and specificity, making it an invaluable tool for researchers investigating cellular health and apoptosis. Its unique structure allows for effective staining of live cells, enabling real-time imaging and analysis of mitochondrial dynamics. JC-1's ability to form aggregates in healthy mitochondria and dissociate in depolarized ones provides a clear indication of mitochondrial function, making it essential for studies in cell biology, pharmacology, and toxicology.

In addition to its applications in basic research, JC-1 is also employed in drug discovery and development, particularly in assessing the efficacy of compounds aimed at improving mitochondrial function. Its versatility extends to various fields, including cancer research, neurobiology, and cardiology, where understanding mitochondrial health is crucial. With its proven track record and reliable performance, JC-1 stands out as a preferred choice for scientists seeking to explore the intricate roles of mitochondria in health and disease.

Synonyms
5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanineiodide, 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanineiodide, CBIC2(3)
CAS Number
3520-43-2
Purity
≥ 97% (HPLC)
Grade
suitable for Hematology & Histology
Molecular Formula
C25H27Cl4IN4
Molecular Weight
652.23
MDL Number
MFCD00188475
PubChem ID
202486
Appearance
Red solid
Conditions
Store at RT
General Information
Synonyms
5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanineiodide, 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanineiodide, CBIC2(3)
CAS Number
3520-43-2
Purity
≥ 97% (HPLC)
Grade
suitable for Hematology & Histology
Molecular Formula
C25H27Cl4IN4
Molecular Weight
652.23
MDL Number
MFCD00188475
PubChem ID
202486
Appearance
Red solid
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

JC-1 is widely utilized in research focused on:

  • Cellular Imaging: JC-1 is commonly used as a fluorescent dye to assess mitochondrial membrane potential in live cells, providing insights into cellular health and function.
  • Apoptosis Studies: Researchers leverage JC-1 to differentiate between healthy and apoptotic cells, making it a valuable tool in cancer research and drug development.
  • Drug Screening: The compound is employed in high-throughput screening assays to evaluate the effects of potential therapeutic agents on mitochondrial function.
  • Neuroscience Research: JC-1 aids in studying neurodegenerative diseases by monitoring mitochondrial dysfunction, which is often a key factor in these conditions.
  • Environmental Toxicology: The dye is used to assess the impact of environmental toxins on cellular health, helping to identify harmful substances and their mechanisms of action.

Citations