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Catalog Number:
38047
CAS Number:
89226-75-5
Manidipine dihydrochloride
Purity:
98 - 101% (Assay)
Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl ester dihydrochloride, 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride
Hazmat
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Product Information

Manidipine dihydrochloride is a potent calcium channel blocker primarily utilized in the management of hypertension and angina pectoris. This compound operates by inhibiting the influx of calcium ions through L-type calcium channels, leading to vasodilation and a subsequent reduction in blood pressure. Its unique structure, featuring a benzhydryl piperazine moiety, enhances its pharmacological profile, making it effective in treating cardiovascular conditions. Researchers and healthcare professionals appreciate its dual action, which not only lowers blood pressure but also improves blood flow, providing a comprehensive approach to cardiovascular health.

In addition to its therapeutic applications, Manidipine dihydrochloride is of interest in pharmaceutical research for developing novel antihypertensive therapies. Its favorable pharmacokinetic properties, including a long half-life and minimal side effects, make it a valuable candidate for further studies. The compound's ability to target specific calcium channels allows for tailored treatment options, potentially leading to improved patient outcomes. With its established efficacy and safety profile, Manidipine dihydrochloride stands out as a reliable choice for both clinical and research applications.

Synonyms
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl ester dihydrochloride, 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride
CAS Number
89226-75-5
Purity
98 - 101% (Assay)
Molecular Formula
C35H38N4O6·2HCl
Molecular Weight
683.63
MDL Number
MFCD00896434
PubChem ID
150762
Melting Point
~207 ?C (dec.)
Appearance
Yellow or light yellow crystalline
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl ester dihydrochloride, 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride
CAS Number
89226-75-5
Purity
98 - 101% (Assay)
Molecular Formula
C35H38N4O6·2HCl
Molecular Weight
683.63
MDL Number
MFCD00896434
PubChem ID
150762
Melting Point
~207 ?C (dec.)
Appearance
Yellow or light yellow crystalline
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Manidipine dihydrochloride is widely utilized in research focused on:

  • Hypertension Treatment: This compound is primarily used in the pharmaceutical industry for managing high blood pressure, providing effective vasodilation and reducing cardiovascular risks.
  • Cardiovascular Research: Researchers often explore its effects on heart health, studying its mechanisms to improve blood flow and reduce strain on the heart.
  • Combination Therapies: It is frequently combined with other antihypertensive agents to enhance therapeutic efficacy, allowing for lower doses and reduced side effects.
  • Drug Development: In the field of medicinal chemistry, it serves as a model compound for developing new antihypertensive medications, guiding the design of more effective and safer drugs.
  • Clinical Trials: Manidipine dihydrochloride is often involved in clinical studies to assess its long-term effects and benefits, contributing valuable data to the medical community.

Citations