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Catalog Number:
38155
CAS Number:
518-28-5
Podophyllotoxin
Purity:
≥ 95% (HPLC)
Hazmat
Documents
$39.56 /1G
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Product Information

Podophyllotoxin is a naturally occurring compound extracted from the roots of the Podophyllum plant, particularly Podophyllum peltatum. This potent lignan is renowned for its significant applications in the pharmaceutical industry, particularly in the development of anticancer therapies. Podophyllotoxin acts as a powerful inhibitor of cell division, making it a crucial component in the formulation of chemotherapeutic agents such as etoposide and teniposide, which are used to treat various malignancies, including testicular cancer and certain types of leukemia.

In addition to its anticancer properties, Podophyllotoxin has demonstrated antiviral activity, particularly against human papillomavirus (HPV), making it a valuable compound in the development of topical treatments for warts and other HPV-related conditions. Its unique structure and mechanism of action provide researchers with a versatile tool for exploring new therapeutic avenues. With its proven efficacy and broad spectrum of applications, Podophyllotoxin continues to be a focal point for innovation in drug development and therapeutic research.

CAS Number
518-28-5
Purity
≥ 95% (HPLC)
Molecular Formula
C22H22O8
Molecular Weight
414.41
MDL Number
MFCD00075290
PubChem ID
4865
Melting Point
177 - 185 ?C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -125 to -133 ° (C=1 in CHCl3)
Conditions
Store at 2 - 8 °C
General Information
CAS Number
518-28-5
Purity
≥ 95% (HPLC)
Molecular Formula
C22H22O8
Molecular Weight
414.41
MDL Number
MFCD00075290
PubChem ID
4865
Melting Point
177 - 185 ?C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -125 to -133 ° (C=1 in CHCl3)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Podophyllotoxin is widely utilized in research focused on:

  • Anticancer Treatments: This compound is a key ingredient in the development of chemotherapeutic agents, particularly for treating testicular cancer and certain types of leukemia. Its ability to inhibit cell division makes it effective in targeting rapidly dividing cancer cells.
  • Antiviral Applications: Podophyllotoxin has shown promise in treating viral infections, particularly human papillomavirus (HPV). It is used in topical treatments for warts caused by HPV, providing a non-invasive option for patients.
  • Pharmaceutical Research: Researchers are exploring its potential as a lead compound for synthesizing new derivatives with enhanced efficacy and reduced toxicity. This opens doors for innovative drug development in oncology and virology.
  • Natural Product Chemistry: As a naturally occurring compound, it serves as a model for studying plant-derived substances. This research can lead to the discovery of new therapeutic agents and contribute to the field of herbal medicine.
  • Biochemical Studies: Podophyllotoxin is used in laboratory settings to study its mechanisms of action on cellular processes. Understanding these mechanisms can help in designing better-targeted therapies for various diseases.

Citations