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Catalog Number:
37923
CAS Number:
184475-35-2
Gefitinib
Purity:
≥ 99% (HPLC)
Synonym(s):
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
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Product Information

Gefitinib is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, primarily used in the treatment of non-small cell lung cancer (NSCLC). This compound has gained significant attention in oncology due to its ability to block the signaling pathways that promote tumor growth and survival, making it a critical therapeutic agent for patients with specific EGFR mutations. Researchers and healthcare professionals appreciate Gefitinib for its targeted action, which minimizes damage to healthy cells compared to traditional chemotherapy, thereby enhancing patient quality of life during treatment.

In addition to its primary application in cancer therapy, Gefitinib is also being explored in combination with other agents to improve treatment outcomes in various malignancies. Its unique chemical structure allows for effective binding to the EGFR, providing a clear advantage over non-selective treatments. As ongoing studies continue to reveal its potential in personalized medicine, Gefitinib remains a valuable compound in the pharmaceutical landscape, offering hope for improved survival rates and better management of lung cancer.

Synonyms
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
CAS Number
184475-35-2
Purity
≥ 99% (HPLC)
Molecular Formula
C22H24ClFN4O3
Molecular Weight
446.91
MDL Number
MFCD04307832
PubChem ID
123631
Melting Point
194 - 198 ?C (Lit.)
Appearance
White to off-white powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
CAS Number
184475-35-2
Purity
≥ 99% (HPLC)
Molecular Formula
C22H24ClFN4O3
Molecular Weight
446.91
MDL Number
MFCD04307832
PubChem ID
123631
Melting Point
194 - 198 ?C (Lit.)
Appearance
White to off-white powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Gefitinib is widely utilized in research focused on:

  • Targeted Cancer Therapy: Primarily used in the treatment of non-small cell lung cancer (NSCLC), Gefitinib inhibits specific growth factor receptors, leading to reduced tumor growth and improved patient outcomes.
  • Personalized Medicine: Its application in genetic testing allows healthcare providers to tailor treatments based on the presence of specific mutations in patients, enhancing treatment efficacy and minimizing side effects.
  • Combination Therapy Research: Researchers are exploring Gefitinib's effectiveness when combined with other cancer treatments, potentially improving overall survival rates and reducing resistance in cancer cells.
  • Pharmaceutical Development: The compound serves as a model for developing new anti-cancer drugs, providing insights into drug design and the mechanisms of action against similar tumors.
  • Clinical Trials: Gefitinib is frequently involved in clinical studies aimed at understanding its long-term effects and potential benefits in various cancer types, contributing to the advancement of oncological therapies.

Citations