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Catalog Number:
37899
CAS Number:
129453-61-8
Fulvestrant
Grade:
Meets USP specification
Purity:
97 - 102% (Assay on anhydrous basis)
Synonym(s):
(7a,17ß)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol, ICI 182780
Documents
$145.52 /25MG
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Product Information

Fulvestrant is a potent selective estrogen receptor downregulator (SERD) primarily utilized in the treatment of hormone receptor-positive breast cancer in postmenopausal women. This compound works by binding to estrogen receptors, leading to their degradation and effectively reducing estrogen-driven tumor growth. Its unique mechanism of action distinguishes Fulvestrant from traditional aromatase inhibitors, making it a valuable option for patients who have developed resistance to other therapies.

In clinical settings, Fulvestrant has demonstrated significant efficacy in improving progression-free survival rates when used alone or in combination with other targeted therapies. Its ability to directly target and downregulate estrogen receptors provides a strategic advantage in managing advanced breast cancer, particularly in cases where other treatments have failed. Researchers and healthcare professionals appreciate Fulvestrant for its role in personalized medicine, allowing for tailored treatment plans that enhance patient outcomes.

Synonyms
(7a,17ß)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol, ICI 182780
CAS Number
129453-61-8
Purity
97 - 102% (Assay on anhydrous basis)
Grade
Meets USP specification
Molecular Formula
C32H47F5O3S
Molecular Weight
606.78
MDL Number
MFCD00903953
PubChem ID
3478439
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 108 - 115 ° (C=20 mg/mL in Methanol)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(7a,17ß)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol, ICI 182780
CAS Number
129453-61-8
Purity
97 - 102% (Assay on anhydrous basis)
Grade
Meets USP specification
Molecular Formula
C32H47F5O3S
Molecular Weight
606.78
MDL Number
MFCD00903953
PubChem ID
3478439
Appearance
White to almost white powder to crystal
Optical Rotation
[a]20D = 108 - 115 ° (C=20 mg/mL in Methanol)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fulvestrant is widely utilized in research focused on:

  • Breast Cancer Treatment: Primarily used as a therapeutic agent for hormone receptor-positive breast cancer, it helps in reducing tumor size and preventing cancer progression.
  • Hormonal Therapy Research: Serves as a critical tool in studying estrogen receptor signaling pathways, aiding researchers in developing new hormonal therapies.
  • Combination Therapy Studies: Often investigated in combination with other cancer treatments to enhance efficacy, providing insights into multi-drug resistance mechanisms.
  • Pharmacokinetics and Pharmacodynamics: Used in clinical trials to understand its absorption, distribution, metabolism, and excretion, which is vital for optimizing dosing regimens.
  • Biomarker Development: Plays a role in identifying biomarkers for treatment response, helping to tailor personalized medicine approaches for patients.

Citations