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Catalog Number:
37874
CAS Number:
21679-14-1
Fludarabine
Purity:
≥ 99% (HPLC)
Synonym(s):
9-β-D-Arabinofuranosyl-2-fluoroadenine, 2-Fluoroadenine arabinosid
Documents
$25.20 /250MG
Pack Size Availability Price
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Product Information

Fludarabine is a potent nucleoside analog that plays a crucial role in the treatment of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. This compound mimics the structure of natural nucleosides, allowing it to interfere with DNA synthesis and repair, which is essential for rapidly dividing cancer cells. Its unique mechanism of action not only enhances the efficacy of chemotherapy regimens but also reduces the risk of resistance, making it a valuable asset in oncological therapies.

In addition to its primary applications in oncology, Fludarabine is also being explored for use in combination therapies, enhancing the effectiveness of other agents in treating various cancers. Its favorable pharmacokinetic profile allows for flexible dosing regimens, which can be tailored to individual patient needs. Researchers and healthcare professionals appreciate Fludarabine for its ability to improve patient outcomes while minimizing side effects, making it a preferred choice in targeted cancer therapies.

Synonyms
9-β-D-Arabinofuranosyl-2-fluoroadenine, 2-Fluoroadenine arabinosid
CAS Number
21679-14-1
Purity
≥ 99% (HPLC)
Molecular Formula
C10H12FN5O4
Molecular Weight
285.24
MDL Number
MFCD00132942
PubChem ID
3367
Melting Point
252 - 258 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 10 - 14 °
Conditions
Store at 2 - 8 °C
General Information
Synonyms
9-β-D-Arabinofuranosyl-2-fluoroadenine, 2-Fluoroadenine arabinosid
CAS Number
21679-14-1
Purity
≥ 99% (HPLC)
Molecular Formula
C10H12FN5O4
Molecular Weight
285.24
MDL Number
MFCD00132942
PubChem ID
3367
Melting Point
252 - 258 ?C
Appearance
White crystalline powder
Optical Rotation
[a]20D = 10 - 14 °
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Fludarabine is widely utilized in research focused on:

  • Cancer Treatment: Primarily used in the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, Fludarabine is effective in targeting and inhibiting the growth of cancerous cells.
  • Immunosuppressive Therapy: It is employed in preparing patients for stem cell transplants by suppressing the immune system, thereby reducing the risk of transplant rejection.
  • Combination Chemotherapy: Fludarabine is often combined with other chemotherapeutic agents to enhance efficacy against various hematological malignancies, providing a synergistic effect that can improve patient outcomes.
  • Research in Molecular Biology: Used as a tool in laboratory studies, it helps researchers understand the mechanisms of DNA synthesis and repair, contributing to advancements in cancer biology.
  • Clinical Trials: Fludarabine is frequently involved in clinical trials aimed at exploring new treatment regimens for blood cancers, offering hope for improved therapies and patient care.

Citations