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Catalog Number:
37789
CAS Number:
3094-09-5
5'-Deoxy-5-fluorouridine
Purity:
≥ 98% (NMR)
Synonym(s):
5'-dFUrd, 1-(5-Deoxy-ß-D-ribofuranosyl)-5-fluorouracil
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Product Information

5'-Deoxy-5-fluorouridine is a fluorinated nucleoside analog that has garnered significant attention in the pharmaceutical and biochemistry sectors due to its potential as an antiviral and anticancer agent. This compound is recognized for its ability to inhibit nucleic acid synthesis, making it a valuable tool in the development of therapeutic agents targeting viral infections and certain types of cancer. Its unique structure allows it to mimic natural nucleosides, facilitating its incorporation into RNA and DNA, which can disrupt cellular processes in rapidly dividing cells. Researchers have explored its applications in combination therapies, particularly in the treatment of cancers such as leukemia and solid tumors, where it can enhance the efficacy of existing chemotherapeutic agents.

Additionally, 5'-Deoxy-5-fluorouridine has shown promise in the field of molecular biology as a reagent for studying nucleic acid metabolism and function. Its ability to selectively target and inhibit specific pathways provides researchers with a powerful tool for dissecting complex biological processes. The compound's favorable solubility and stability further enhance its utility in laboratory settings, making it an essential addition to any researcher's toolkit focused on nucleic acid research and therapeutic development.

Synonyms
5'-dFUrd, 1-(5-Deoxy-ß-D-ribofuranosyl)-5-fluorouracil
CAS Number
3094-09-5
Purity
≥ 98% (NMR)
Molecular Formula
C9H11FN2O5
Molecular Weight
246.19
MDL Number
MFCD00866530
PubChem ID
3159
Melting Point
189 - 193 ?C (Lit.)
Appearance
White solid
Optical Rotation
[a]20D = 18 - 22 ° (C=1 in H2O) (Lit.)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
5'-dFUrd, 1-(5-Deoxy-ß-D-ribofuranosyl)-5-fluorouracil
CAS Number
3094-09-5
Purity
≥ 98% (NMR)
Molecular Formula
C9H11FN2O5
Molecular Weight
246.19
MDL Number
MFCD00866530
PubChem ID
3159
Melting Point
189 - 193 ?C (Lit.)
Appearance
White solid
Optical Rotation
[a]20D = 18 - 22 ° (C=1 in H2O) (Lit.)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5'-Deoxy-5-fluorouridine is widely utilized in research focused on:

  • Cancer Treatment: This compound is a key component in developing chemotherapeutic agents, particularly for targeting specific types of cancers by inhibiting DNA synthesis.
  • Antiviral Research: It shows promise in antiviral applications, particularly against viral infections like hepatitis and HIV, by disrupting viral replication processes.
  • Pharmaceutical Development: Used in the synthesis of nucleoside analogs, it aids in the creation of new antiviral and anticancer drugs, enhancing therapeutic options.
  • Biochemical Studies: Researchers utilize this compound to study nucleic acid metabolism and the mechanisms of action of various enzymes, providing insights into cellular processes.
  • Drug Resistance Research: It helps in understanding and overcoming drug resistance in cancer therapies, allowing for the development of more effective treatment regimens.

Citations