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Catalog Number:
37738
CAS Number:
305-03-3
Chlorambucil
Purity:
≥ 98% (Assay by titration, GC)
Synonym(s):
4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric acid
Hazmat
Documents
$90.34 /200MG
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Product Information

Chlorambucil is a potent alkylating agent primarily used in the treatment of certain types of cancer, particularly chronic lymphocytic leukemia (CLL) and lymphoma. This compound functions by interfering with the DNA replication process, making it effective in targeting rapidly dividing cancer cells. Its ability to penetrate cell membranes allows for effective delivery within the body, enhancing its therapeutic efficacy. Chlorambucil is also recognized for its relatively mild side effect profile compared to other chemotherapeutic agents, making it a preferred choice in long-term cancer management.

In addition to its primary use in oncology, Chlorambucil has applications in research settings, particularly in studies focused on cancer biology and drug resistance mechanisms. Its unique properties allow researchers to explore the effects of DNA damage and repair pathways, contributing to the development of novel therapeutic strategies. With its established role in cancer treatment and ongoing research applications, Chlorambucil remains a valuable compound in both clinical and laboratory environments.

Synonyms
4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric acid
CAS Number
305-03-3
Purity
≥ 98% (Assay by titration, GC)
Molecular Formula
C14H19Cl2NO2
Molecular Weight
304.21
MDL Number
MFCD00021783
PubChem ID
2708
Melting Point
65 - 69 ?C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric acid
CAS Number
305-03-3
Purity
≥ 98% (Assay by titration, GC)
Molecular Formula
C14H19Cl2NO2
Molecular Weight
304.21
MDL Number
MFCD00021783
PubChem ID
2708
Melting Point
65 - 69 ?C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Chlorambucil is widely utilized in research focused on:

  • Cancer Treatment: Primarily used in oncology, it serves as a chemotherapy agent for treating chronic lymphocytic leukemia (CLL) and Hodgkin's lymphoma, helping to slow down cancer cell growth.
  • Immunosuppressive Therapy: Employed in organ transplantation and autoimmune diseases, it helps suppress the immune response, reducing the risk of organ rejection and managing conditions like rheumatoid arthritis.
  • Pharmaceutical Research: Used in drug development studies, chlorambucil aids researchers in understanding the mechanisms of action of alkylating agents and their effects on DNA, providing insights for creating new therapies.
  • Veterinary Medicine: It is also applied in veterinary oncology for treating certain types of cancers in animals, offering a therapeutic option where traditional treatments may be less effective.
  • Combination Therapies: Often used in combination with other chemotherapeutic agents, chlorambucil enhances treatment efficacy, allowing for lower doses of each drug and potentially reducing side effects.

Citations