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Catalog Number:
37608
CAS Number:
54301-15-4
Amsacrine hydrochloride
Purity:
≥ 98% (HPLC)
Synonym(s):
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA
Hazmat
Documents
$168.35 /20MG
Pack Size Availability Price
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Product Information

Amsacrine hydrochloride is a potent anthracycline derivative known for its significant role in cancer therapy, particularly in the treatment of acute lymphoblastic leukemia and other hematological malignancies. This compound exhibits a unique mechanism of action by intercalating into DNA, thereby inhibiting topoisomerase II, which is crucial for DNA replication and repair. Its efficacy in clinical settings has made it a valuable agent in combination therapies, enhancing the overall effectiveness of treatment regimens.

Researchers and industry professionals appreciate Amsacrine hydrochloride for its ability to overcome drug resistance often seen with other chemotherapeutic agents. Its targeted action and favorable pharmacological profile make it a preferred choice in oncology research and drug development. Additionally, its applications extend to laboratory settings, where it serves as a vital tool for studying cellular processes and drug interactions. With ongoing research into its potential uses, Amsacrine hydrochloride continues to hold promise for advancing cancer treatment strategies.

Synonyms
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA
CAS Number
54301-15-4
Purity
≥ 98% (HPLC)
Molecular Formula
C21H19N3O3S·HCl
Molecular Weight
429.92
MDL Number
MFCD07799963
PubChem ID
148673
Melting Point
288 ?C
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at RT
General Information
Synonyms
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride, m-AMSA
CAS Number
54301-15-4
Purity
≥ 98% (HPLC)
Molecular Formula
C21H19N3O3S·HCl
Molecular Weight
429.92
MDL Number
MFCD07799963
PubChem ID
148673
Melting Point
288 ?C
Appearance
Light yellow to amber to dark green powder to crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Amsacrine hydrochloride is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily used as an antineoplastic agent in chemotherapy, particularly for treating acute leukemia. Its ability to intercalate DNA helps inhibit cancer cell proliferation.
  • Pharmaceutical Development: Researchers explore its efficacy in combination therapies, enhancing the effectiveness of other anticancer drugs, which can lead to improved patient outcomes.
  • Cellular Mechanism Studies: Amsacrine hydrochloride is valuable in laboratory studies investigating cellular mechanisms of drug resistance, helping scientists understand how cancer cells evade treatment.
  • Drug Formulation Research: The compound is used in developing new drug formulations, focusing on improving bioavailability and reducing side effects, which is crucial for patient compliance.
  • Biochemical Assays: It serves as a tool in various biochemical assays to study DNA interactions and the effects of DNA damage, providing insights into fundamental biological processes.

Citations