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Catalog Number:
23019
CAS Number:
64-86-8
-)-Colchicine
Grade:
Meets USP specification
Purity:
94 - 101% (HPLC)
Hazmat
Documents
$77.82 /1G
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Product Information

(-)-Colchicine is a potent alkaloid derived from the plant Colchicum autumnale, commonly known as the autumn crocus. This compound is renowned for its ability to inhibit microtubule polymerization, making it a valuable tool in both research and clinical settings. Its unique mechanism of action allows it to disrupt cell division, which is particularly useful in cancer research and the treatment of gout, where it alleviates inflammation by targeting neutrophil migration. Additionally, (-)-Colchicine has applications in genetic studies, particularly in the field of cytogenetics, where it is used to induce polyploidy in plants, enhancing crop yields and resilience.

Researchers and industry professionals appreciate (-)-Colchicine for its versatility and effectiveness. Its ability to modulate cellular processes makes it a critical compound in drug development and therapeutic applications. Compared to similar compounds, (-)-Colchicine offers a well-characterized profile with established dosage guidelines, ensuring safety and efficacy in its applications. Whether in a laboratory setting or clinical practice, (-)-Colchicine stands out as a reliable choice for those seeking to explore cellular dynamics or manage inflammatory conditions.

CAS Number
64-86-8
Purity
94 - 101% (HPLC)
Grade
Meets USP specification
Molecular Formula
C22H25NO6
Molecular Weight
399.43
MDL Number
MFCD00078484
PubChem ID
2833
Appearance
White to Pale yellow to green crystalline
Optical Rotation
[a]D20 = -240 to -250 º (C=1 in Alcohol)
Conditions
Store at 0 - 8 °C
General Information
CAS Number
64-86-8
Purity
94 - 101% (HPLC)
Grade
Meets USP specification
Molecular Formula
C22H25NO6
Molecular Weight
399.43
MDL Number
MFCD00078484
PubChem ID
2833
Appearance
White to Pale yellow to green crystalline
Optical Rotation
[a]D20 = -240 to -250 º (C=1 in Alcohol)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(-)-Colchicine is widely utilized in research focused on:

  • Gout Treatment: It is a well-known medication for managing gout attacks by reducing inflammation and pain associated with the condition.
  • Cell Biology: Researchers use colchicine to study cell division, as it disrupts the formation of microtubules, allowing scientists to investigate mitosis and cellular processes.
  • Genetic Research: In plant breeding, colchicine is applied to induce polyploidy, which can lead to the development of new plant varieties with desirable traits.
  • Cancer Research: Its ability to inhibit cell division makes it a valuable tool in cancer research, helping to understand tumor growth and the effects of chemotherapy.
  • Inflammatory Diseases: Colchicine is also being explored for its potential benefits in treating other inflammatory conditions, such as familial Mediterranean fever, showcasing its versatility in therapeutic applications.

Citations