Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
38729
CAS Number:
143-62-4
Digitoxigenin
Purity:
≥ 95% (Assay on dried basis)
Synonym(s):
3β,14-Dihydroxy-5β,20(22)-cardenolide, 3,14,21-Trihydroxy-20(22)-norcholenic acid lactone
Hazmat
Documents
$130.00 /10MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Digitoxigenin is a naturally occurring cardiac glycoside that plays a significant role in the field of pharmacology, particularly in the development of treatments for heart conditions. This compound is recognized for its ability to enhance cardiac contractility, making it valuable in the management of heart failure and arrhythmias. Its unique structure allows it to interact effectively with sodium-potassium ATPase, leading to increased intracellular calcium levels, which is crucial for improving heart muscle function.

In addition to its therapeutic applications, Digitoxigenin is also utilized in research settings to study the mechanisms of cardiac glycosides and their effects on cellular processes. Its potential as a lead compound for developing new cardiovascular drugs is noteworthy, as it offers a foundation for synthesizing derivatives with improved efficacy and reduced side effects. Researchers and industry professionals can leverage Digitoxigenin's properties to explore innovative treatments and enhance existing therapies in cardiology.

Synonyms
3β,14-Dihydroxy-5β,20(22)-cardenolide, 3,14,21-Trihydroxy-20(22)-norcholenic acid lactone
CAS Number
143-62-4
Purity
≥ 95% (Assay on dried basis)
Molecular Formula
C23H34O4
Molecular Weight
374.52
MDL Number
MFCD00003687
PubChem ID
274159
Melting Point
253 ?C
Appearance
White or almost white powder without mechanical impurities
Optical Rotation
[a]20D = 15 - 20 ° (C = 1 in MeOH)
Conditions
Store at RT
Warnings
DOT/IMDG same
General Information
Synonyms
3β,14-Dihydroxy-5β,20(22)-cardenolide, 3,14,21-Trihydroxy-20(22)-norcholenic acid lactone
CAS Number
143-62-4
Purity
≥ 95% (Assay on dried basis)
Molecular Formula
C23H34O4
Molecular Weight
374.52
MDL Number
MFCD00003687
PubChem ID
274159
Melting Point
253 ?C
Appearance
White or almost white powder without mechanical impurities
Optical Rotation
[a]20D = 15 - 20 ° (C = 1 in MeOH)
Conditions
Store at RT
Warnings
DOT/IMDG same
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
Yes
Antibiotic
No
DEA-regulated
No
Warnings
DOT/IMDG same
Applications

Digitoxigenin is widely utilized in research focused on:

  • Pharmaceutical Development: This compound is a key precursor in the synthesis of cardiac glycosides, which are used to treat heart conditions such as atrial fibrillation and heart failure.
  • Biochemical Research: It serves as a valuable tool in studies investigating the mechanisms of action of steroid hormones and their effects on cellular processes.
  • Natural Product Chemistry: Researchers use digitoxigenin to explore the biosynthesis of plant-derived compounds, enhancing our understanding of natural product pathways.
  • Toxicology Studies: Its role in evaluating the toxicity of cardiac glycosides helps in assessing safety profiles for new drug formulations.
  • Pharmacognosy: This compound is studied for its potential therapeutic effects and benefits in traditional medicine, particularly in herbal remedies.

Citations