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Catalog Number:
38235
CAS Number:
85416-75-7
(R)-(-)-Rolipram
Purity:
≥ 98% (Chiral HPLC, HPLC)
Synonym(s):
(R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Documents
$209.61 /10MG
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Product Information

(R)-(-)-Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, recognized for its potential therapeutic applications in treating various inflammatory and neurodegenerative conditions. This compound has garnered attention in research for its ability to enhance cognitive function and reduce inflammation, making it a valuable candidate in the development of treatments for diseases such as Alzheimer's and multiple sclerosis. Its unique structure allows for targeted action, minimizing side effects typically associated with broader-spectrum PDE inhibitors.

In addition to its pharmaceutical relevance, (R)-(-)-Rolipram is utilized in preclinical studies to explore its effects on memory enhancement and mood regulation. Researchers appreciate its specificity, which can lead to more effective therapies with fewer adverse reactions. The compound's ability to modulate cyclic AMP levels positions it as a promising agent in both academic and clinical settings, paving the way for innovative approaches in neuropharmacology and beyond.

Synonyms
(R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number
85416-75-7
Purity
≥ 98% (Chiral HPLC, HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD03093861
PubChem ID
5092
Melting Point
132 - 136 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -29 to -34 ° (C=0.5 in Methanol)
Conditions
Store at < 0 °C
General Information
Synonyms
(R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number
85416-75-7
Purity
≥ 98% (Chiral HPLC, HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD03093861
PubChem ID
5092
Melting Point
132 - 136 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = -29 to -34 ° (C=0.5 in Methanol)
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(R)-(-)-Rolipram is widely utilized in research focused on

  • Neurological Disorders: This compound is being studied for its potential in treating conditions like depression and anxiety by inhibiting phosphodiesterase-4 (PDE4), which can enhance mood and cognitive function.
  • Anti-inflammatory Applications: Researchers are exploring its use in reducing inflammation, particularly in diseases such as asthma and chronic obstructive pulmonary disease (COPD), where PDE4 inhibition can lead to decreased airway inflammation.
  • Memory Enhancement: Studies suggest that (R)-(-)-Rolipram may improve memory and learning processes, making it a candidate for research in age-related cognitive decline and neurodegenerative diseases like Alzheimer's.
  • Potential Cancer Research: There is ongoing investigation into its role in cancer therapy, particularly in enhancing the efficacy of certain chemotherapeutic agents by modulating the immune response.
  • Pharmaceutical Development: The compound serves as a valuable tool in drug formulation studies, particularly in optimizing formulations aimed at targeting specific neurological pathways.

Citations