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Catalog Number:
38109
CAS Number:
82956-11-4
Nafamostat mesylate
Purity:
≥ 98% (HPLC)
Synonym(s):
6-Amidino-2-naphthyl 4-guanidinobenzoate Bis(methanesulfonate), 4-Guanidinobenzoic acid 6-amidino-2-naphthyl esterbis(methanesulfonate)
Documents
$68.20 /20MG
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Product Information

Nafamostat mesylate is a potent synthetic serine protease inhibitor, primarily recognized for its application in the treatment of various medical conditions, including pancreatitis and as an antiviral agent. This compound has garnered attention for its ability to inhibit the activity of several proteases, making it a valuable tool in both clinical and research settings. Its unique mechanism of action allows for the modulation of inflammatory responses, which is particularly beneficial in managing acute and chronic inflammatory diseases. Researchers have also explored its potential in the treatment of COVID-19, where it has shown promise in inhibiting viral entry into host cells.

In addition to its therapeutic applications, Nafamostat mesylate is utilized in laboratory settings for studying protease functions and their roles in various biological processes. Its effectiveness in modulating protease activity makes it an essential compound for researchers investigating the mechanisms of disease and potential therapeutic interventions. With its multifaceted applications, Nafamostat mesylate stands out as a critical compound for both clinical and research purposes, offering significant benefits in the fields of medicine and biochemistry.

Synonyms
6-Amidino-2-naphthyl 4-guanidinobenzoate Bis(methanesulfonate), 4-Guanidinobenzoic acid 6-amidino-2-naphthyl esterbis(methanesulfonate)
CAS Number
82956-11-4
Purity
≥ 98% (HPLC)
Molecular Formula
C19H17N5O2·2CH4O3S
Molecular Weight
539.58
MDL Number
MFCD00941430
PubChem ID
5311180
Melting Point
257 - 259 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
6-Amidino-2-naphthyl 4-guanidinobenzoate Bis(methanesulfonate), 4-Guanidinobenzoic acid 6-amidino-2-naphthyl esterbis(methanesulfonate)
CAS Number
82956-11-4
Purity
≥ 98% (HPLC)
Molecular Formula
C19H17N5O2·2CH4O3S
Molecular Weight
539.58
MDL Number
MFCD00941430
PubChem ID
5311180
Melting Point
257 - 259 °C
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Nafamostat mesylate is widely utilized in research focused on:

  • Antiviral Therapy: This compound is effective against various viruses, including coronaviruses, making it a valuable candidate in the development of antiviral medications.
  • Thrombolytic Applications: Nafamostat is used in the treatment of acute pancreatitis and other conditions requiring rapid anticoagulation, providing a quick response in critical care settings.
  • Research on Blood Coagulation: It serves as a tool for studying coagulation pathways, helping researchers understand blood clotting mechanisms and potential treatments for clotting disorders.
  • Kidney Protection: In renal research, it has shown promise in protecting kidney cells from damage during ischemic events, which is crucial for developing therapies for kidney diseases.
  • Drug Development: Its unique properties allow researchers to explore new formulations and combinations in drug development, particularly in the fields of oncology and infectious diseases.

Citations