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Geldanamycin from Streptomyces hygroscopicus
Geldanamycin is widely utilized in research focused on
- Cancer Treatment: This compound is known for its ability to inhibit heat shock protein 90 (HSP90), which is crucial for the stability of many oncogenic proteins. Researchers are exploring its potential as a targeted therapy in various cancer types.
- Drug Development: Geldanamycin serves as a lead compound in the development of novel anticancer drugs. Its unique mechanism of action provides a foundation for creating more effective therapies with fewer side effects.
- Biotechnology: In the field of biotechnology, it is used to study protein folding and degradation processes, helping scientists understand cellular stress responses and develop strategies to combat diseases related to protein misfolding.
- Neurodegenerative Disease Research: The compound is being investigated for its potential benefits in treating neurodegenerative diseases, as it may help in the stabilization of proteins involved in these conditions.
- Combination Therapies: Geldanamycin is often used in combination with other therapeutic agents to enhance the efficacy of treatment regimens, particularly in overcoming drug resistance in cancer therapies.
General Information
Properties
Safety and Regulations
Applications
Geldanamycin is widely utilized in research focused on
- Cancer Treatment: This compound is known for its ability to inhibit heat shock protein 90 (HSP90), which is crucial for the stability of many oncogenic proteins. Researchers are exploring its potential as a targeted therapy in various cancer types.
- Drug Development: Geldanamycin serves as a lead compound in the development of novel anticancer drugs. Its unique mechanism of action provides a foundation for creating more effective therapies with fewer side effects.
- Biotechnology: In the field of biotechnology, it is used to study protein folding and degradation processes, helping scientists understand cellular stress responses and develop strategies to combat diseases related to protein misfolding.
- Neurodegenerative Disease Research: The compound is being investigated for its potential benefits in treating neurodegenerative diseases, as it may help in the stabilization of proteins involved in these conditions.
- Combination Therapies: Geldanamycin is often used in combination with other therapeutic agents to enhance the efficacy of treatment regimens, particularly in overcoming drug resistance in cancer therapies.
Documents
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
Product Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.
*Catalog Number
*Lot Number
Safety Data Sheets (SDS)
The SDS provides comprehensive safety information on handling, storage, and disposal of the product.
DownloadProduct Specification (PS)
The PS provides a comprehensive breakdown of the product’s properties, including chemical composition, physical state, purity, and storage requirements. It also details acceptable quality ranges and the product's intended applications.
DownloadCertificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
*Catalog Number
*Lot Number
Certificates Of Origin (COO)
This COO confirms the country where the product was manufactured, and also details the materials and components used in it and whether it is derived from natural, synthetic, or other specific sources. This certificate may be required for customs, trade, and regulatory compliance.