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Catalog Number:
38493
CAS Number:
58-58-2
Puromycin dihydrochloride from Streptomyces alboniger powder
Grade:
suitable for cell culture
Purity:
≥ 98% (HPLC)
Synonym(s):
3'-[a-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosinedihydrochloride
Documents
$78.12 /25MG
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Product Information

Puromycin dihydrochloride from *Streptomyces alboniger* powder is a potent antibiotic and a valuable tool in molecular biology and biochemistry. This compound is widely recognized for its ability to inhibit protein synthesis in both prokaryotic and eukaryotic cells, making it an essential reagent in various research applications. Researchers utilize puromycin to select for genetically modified cells, as it allows for the effective identification of successfully transfected cells by inducing cell death in non-transfected cells. Its unique mechanism of action, which mimics aminoacyl-tRNA, enables it to bind to the ribosome and terminate peptide chain elongation, providing a reliable method for studying gene expression and protein function.

In addition to its applications in cell culture, puromycin dihydrochloride is also employed in the development of therapeutic strategies against cancer and infectious diseases. Its ability to selectively target and eliminate specific cell populations makes it a valuable asset in the field of targeted therapy. With its proven efficacy and versatility, puromycin dihydrochloride continues to be an indispensable compound for researchers and industry professionals seeking to advance their work in molecular biology and therapeutic development.

Synonyms
3'-[a-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosinedihydrochloride
CAS Number
58-58-2
Purity
≥ 98% (HPLC)
Grade
suitable for cell culture
Molecular Formula
C22H29N7O5 · 2HCl
Molecular Weight
544.43
MDL Number
MFCD00012691
PubChem ID
16757772
Melting Point
168 - 170 °C
Appearance
White to off-white powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
3'-[a-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosinedihydrochloride
CAS Number
58-58-2
Purity
≥ 98% (HPLC)
Grade
suitable for cell culture
Molecular Formula
C22H29N7O5 · 2HCl
Molecular Weight
544.43
MDL Number
MFCD00012691
PubChem ID
16757772
Melting Point
168 - 170 °C
Appearance
White to off-white powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Puromycin dihydrochloride from Streptomyces alboniger powder is widely utilized in research focused on:

  • Cell Culture Research: This compound is commonly used as a selective agent in cell culture to eliminate untransformed cells, allowing researchers to maintain only those cells that have been successfully modified or transfected.
  • Antibiotic Applications: It serves as an effective antibiotic in microbiological studies, particularly in the selection of genetically modified organisms, ensuring that only the desired strains survive in a mixed population.
  • Biotechnology and Genetic Engineering: Puromycin is essential in the production of recombinant proteins, as it helps in the selection of cells that express the desired genes, streamlining the process of protein synthesis.
  • Cancer Research: Researchers utilize this compound to study the effects of protein synthesis inhibition on cancer cells, providing insights into potential therapeutic strategies for targeting tumor growth.
  • Pharmaceutical Development: It plays a role in drug discovery and development by aiding in the identification of new drug candidates that can effectively inhibit protein synthesis in pathogenic organisms.

Citations