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Catalog Number:
38474
CAS Number:
9041-93-4
Bleomycin sulfate from Streptomyces verticillus 1.5-2.0 units/mg solid
Grade:
suitable for cell culture
Synonym(s):
Bleo, Blexane
Documents
$60.00 /5MG
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Product Information

Bleomycin sulfate from *Streptomyces verticillus* is a potent antitumor antibiotic known for its unique ability to induce DNA strand breaks, making it a valuable agent in cancer therapy. This compound is particularly effective against various types of malignancies, including testicular cancer, Hodgkin's lymphoma, and squamous cell carcinoma. Its mechanism of action involves the formation of free radicals that interact with DNA, leading to cytotoxic effects that are leveraged in clinical settings. Researchers and healthcare professionals appreciate its specificity and efficacy, often utilizing it in combination with other chemotherapeutic agents to enhance treatment outcomes.

In addition to its therapeutic applications, Bleomycin sulfate has been employed in research settings to study DNA damage and repair mechanisms, providing insights into cellular responses to genotoxic stress. Its unique structure and properties allow for targeted applications in both clinical and laboratory environments, making it an essential compound for oncologists and researchers alike. With its proven track record and ongoing relevance in cancer treatment, Bleomycin sulfate remains a critical tool in the fight against cancer.

Synonyms
Bleo, Blexane
CAS Number
9041-93-4
Grade
suitable for cell culture
PubChem ID
21864427
Appearance
White crystalline powder
Conditions
Store at 0 - 8 °C
Potency
1.2 - 1.7 u/mg
General Information
Synonyms
Bleo, Blexane
CAS Number
9041-93-4
Grade
suitable for cell culture
PubChem ID
21864427
Appearance
White crystalline powder
Conditions
Store at 0 - 8 °C
Potency
1.2 - 1.7 u/mg
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Bleomycin sulfate from Streptomyces verticillus is widely utilized in research focused on:

  • Cancer Treatment: This compound is primarily known for its role as an anticancer agent, particularly in the treatment of testicular cancer and Hodgkin's lymphoma. Its ability to induce DNA damage in cancer cells makes it a valuable tool in chemotherapy.
  • Research in Antitumor Mechanisms: Researchers use bleomycin to study the mechanisms of tumor suppression and the cellular responses to DNA damage, providing insights that can lead to the development of new cancer therapies.
  • Gene Therapy Applications: Its unique properties allow for the exploration of gene therapy techniques, where it can be used to selectively target and kill cancerous cells while sparing normal tissues, enhancing treatment efficacy.
  • Biomedical Research: The compound is utilized in various laboratory studies to investigate cellular processes, including apoptosis (programmed cell death), which is crucial for understanding cancer biology and treatment responses.
  • Combination Therapies: Bleomycin is often used in combination with other chemotherapeutic agents to enhance the overall effectiveness of cancer treatment regimens, allowing for lower doses of each drug and reducing side effects.

Citations