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Catalog Number:
38380
CAS Number:
364622-82-2
Doripenem monohydrate
Purity:
≥ 98% (HPLC)
Synonym(s):
(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid
Documents
$339.31 /50MG
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Product Information

Doripenem monohydrate is a broad-spectrum carbapenem antibiotic known for its potent antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. This compound is particularly valuable in clinical settings for treating serious infections such as pneumonia, urinary tract infections, and intra-abdominal infections. Its unique structure enhances its stability against beta-lactamases, making it an effective choice for combating resistant bacterial infections. Researchers and healthcare professionals appreciate Doripenem monohydrate for its efficacy and safety profile, which allows for its use in various patient populations, including those with compromised immune systems.

In addition to its clinical applications, Doripenem monohydrate is also utilized in pharmaceutical research and development, where it serves as a benchmark for developing new antibiotics. Its ability to penetrate bacterial cell walls effectively makes it a subject of interest in studies aimed at understanding antibiotic resistance mechanisms. The compound's favorable pharmacokinetic properties, including its distribution and elimination, further enhance its utility in both therapeutic and research contexts, making it a vital asset in the ongoing fight against bacterial infections.

Synonyms
(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid
CAS Number
364622-82-2
Purity
≥ 98% (HPLC)
Molecular Formula
C15H24N4O6S2·H2O
Molecular Weight
438.52
MDL Number
MFCD09749887
PubChem ID
45371286
Melting Point
173 °C (dec.)
Appearance
White to light yellow to light orange powder to crystal
Optical Rotation
32 - 37 ° (C=1, H2O)
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid
CAS Number
364622-82-2
Purity
≥ 98% (HPLC)
Molecular Formula
C15H24N4O6S2·H2O
Molecular Weight
438.52
MDL Number
MFCD09749887
PubChem ID
45371286
Melting Point
173 °C (dec.)
Appearance
White to light yellow to light orange powder to crystal
Optical Rotation
32 - 37 ° (C=1, H2O)
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Doripenem monohydrate is widely utilized in research focused on:

  • Antibiotic Development: This compound is a broad-spectrum antibiotic effective against various bacterial infections, making it crucial for developing new treatments in the pharmaceutical industry.
  • Clinical Applications: Used in hospital settings for treating severe infections, particularly in patients with compromised immune systems, it helps improve patient outcomes and reduce hospital stays.
  • Combination Therapies: Often combined with other antibiotics to enhance efficacy against resistant bacterial strains, it provides a strategic advantage in tackling complex infections.
  • Research in Microbiology: Employed in laboratory studies to understand bacterial resistance mechanisms, aiding researchers in developing more effective antibiotics.
  • Pharmacokinetics Studies: Used in drug formulation research to evaluate absorption and distribution in the body, helping optimize dosing regimens for better therapeutic effects.

Citations