Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
38342
CAS Number:
27314-97-2
Tirapazamine
Purity:
≥ 98% (HPLC)
Synonym(s):
SR 259075, 3-Aminobenzo[e][1,2,4]triazine 1,4-dioxide
Documents
$148.22 /50MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Tirapazamine is a unique chemical compound recognized for its potential in cancer therapy, particularly in the treatment of hypoxic tumors. This compound operates as a bioreductive agent, selectively targeting and damaging hypoxic cancer cells while sparing normal tissues, which makes it a promising candidate in oncology. Its mechanism of action involves the reduction of the compound in low-oxygen environments, leading to the generation of reactive species that induce cell death. This specificity not only enhances therapeutic efficacy but also minimizes side effects commonly associated with traditional chemotherapy.

In addition to its applications in cancer treatment, Tirapazamine has been explored in combination with other therapeutic agents to improve overall treatment outcomes. Researchers have noted its potential in enhancing the effectiveness of radiotherapy, making it a valuable addition to cancer treatment regimens. With ongoing studies and clinical trials, Tirapazamine holds significant promise for advancing cancer therapies and improving patient outcomes, particularly for those with challenging hypoxic tumors.

Synonyms
SR 259075, 3-Aminobenzo[e][1,2,4]triazine 1,4-dioxide
CAS Number
27314-97-2
Purity
≥ 98% (HPLC)
Molecular Formula
C7H6N4O2
Molecular Weight
178.15
MDL Number
MFCD00132954
PubChem ID
135413511
Melting Point
229 - 231 °C (dec.)
Appearance
Orange to red powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
SR 259075, 3-Aminobenzo[e][1,2,4]triazine 1,4-dioxide
CAS Number
27314-97-2
Purity
≥ 98% (HPLC)
Molecular Formula
C7H6N4O2
Molecular Weight
178.15
MDL Number
MFCD00132954
PubChem ID
135413511
Melting Point
229 - 231 °C (dec.)
Appearance
Orange to red powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tirapazamine is widely utilized in research focused on:

  • Cancer Treatment: This compound is being investigated for its ability to selectively target and kill hypoxic tumor cells, making it a promising candidate for enhancing the efficacy of radiotherapy and chemotherapy.
  • Drug Development: Researchers are exploring tirapazamine as a lead compound in developing new anti-cancer drugs, particularly for tumors that are resistant to conventional therapies.
  • Clinical Trials: It has been involved in various clinical trials aimed at assessing its safety and effectiveness in combination with other cancer treatments, providing valuable data for future therapies.
  • Radiation Sensitization: Tirapazamine's unique mechanism of action allows it to sensitize tumor cells to radiation, which can improve treatment outcomes for patients undergoing radiotherapy.
  • Research on Hypoxia: The compound is used in studies examining the role of hypoxia in tumor biology, helping researchers understand how low oxygen levels affect cancer progression and treatment response.

Citations