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Catalog Number:
38297
CAS Number:
58-46-8
Tetrabenazine
Purity:
≥ 99% (HPLC)
Synonym(s):
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
Documents
$232.25 /200MG
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Product Information

Tetrabenazine is a specialized compound primarily utilized in the treatment of movement disorders, particularly in managing chorea associated with Huntington's disease. This therapeutic agent functions as a reversible inhibitor of the vesicular monoamine transporter 2 (VMAT2), leading to a decrease in the release of monoamines, such as dopamine, from presynaptic neurons. Its unique mechanism of action makes it a valuable option for patients experiencing involuntary movements, providing significant relief and improving quality of life.

In addition to its primary use in neurology, Tetrabenazine has shown potential in various research applications, including studies on neurodegenerative diseases and psychiatric disorders. Its ability to modulate neurotransmitter levels opens avenues for exploring new treatment strategies. Researchers and healthcare professionals appreciate Tetrabenazine for its targeted approach and efficacy in symptom management, making it a critical compound in both clinical and research settings.

Synonyms
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
CAS Number
58-46-8
Purity
≥ 99% (HPLC)
Molecular Formula
C19H27NO3
Molecular Weight
317.43
MDL Number
MFCD08461052
PubChem ID
6018
Melting Point
124 - 130 °C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
CAS Number
58-46-8
Purity
≥ 99% (HPLC)
Molecular Formula
C19H27NO3
Molecular Weight
317.43
MDL Number
MFCD08461052
PubChem ID
6018
Melting Point
124 - 130 °C
Appearance
White to light yellow powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Tetrabenazine is widely utilized in research focused on:

  • Neurological Disorders: Primarily used in the treatment of movement disorders such as Huntington's disease and tardive dyskinesia, helping to reduce involuntary movements.
  • Pharmaceutical Development: Serves as a valuable compound in drug formulation studies, particularly in understanding the pharmacokinetics and pharmacodynamics of similar neuroleptic agents.
  • Research on Monoamine Depletion: Acts as a model compound for studying the effects of monoamine depletion in various neurological studies, aiding researchers in understanding mood disorders.
  • Clinical Trials: Frequently involved in clinical trials aimed at evaluating new therapies for movement disorders, providing a benchmark for efficacy and safety.
  • Custom Compounding: Used in compounding pharmacies to create personalized medication regimens for patients with specific needs, ensuring tailored treatment options.

Citations