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Catalog Number:
38295
CAS Number:
89778-27-8
Toremifene citrate
Purity:
≥ 98% (HPLC)
Synonym(s):
(Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butenecitrate, (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanaminecitrate
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Product Information

Toremifene citrate is a selective estrogen receptor modulator (SERM) primarily used in the treatment of hormone receptor-positive breast cancer. This compound exhibits a unique mechanism of action, functioning as an anti-estrogen in breast tissue while acting as an estrogen agonist in other tissues, such as bone. Its ability to selectively target estrogen receptors makes it a valuable option for patients who are intolerant to traditional therapies. Researchers have also explored its potential in treating other conditions, including prostate cancer and as a part of hormone therapy regimens.

In addition to its therapeutic applications, Toremifene citrate has garnered attention for its favorable safety profile compared to other SERMs, making it a preferred choice in certain clinical scenarios. Its effectiveness in reducing the risk of breast cancer recurrence and its role in improving bone density in postmenopausal women further highlight its significance in oncology and endocrinology. With ongoing research, Toremifene citrate continues to demonstrate promise in expanding treatment options for various hormone-related conditions.

Synonyms
(Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butenecitrate, (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanaminecitrate
CAS Number
89778-27-8
Purity
≥ 98% (HPLC)
Molecular Formula
C26H28ClNO·C6H8O7
Molecular Weight
598.09
MDL Number
MFCD01729016
PubChem ID
56008
Melting Point
162 °C(dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
(Z)-4-Chloro-1-(4-dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butenecitrate, (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanaminecitrate
CAS Number
89778-27-8
Purity
≥ 98% (HPLC)
Molecular Formula
C26H28ClNO·C6H8O7
Molecular Weight
598.09
MDL Number
MFCD01729016
PubChem ID
56008
Melting Point
162 °C(dec.)
Appearance
White to almost white powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Toremifene citrate is widely utilized in research focused on:

  • Breast Cancer Treatment: This compound is primarily used as a selective estrogen receptor modulator (SERM) in the treatment of hormone receptor-positive breast cancer, offering an alternative to traditional therapies.
  • Fertility Treatments: Toremifene is explored in reproductive medicine for its potential to stimulate ovulation, providing options for women facing infertility challenges.
  • Bone Health: Research indicates that Toremifene may help in maintaining bone density in postmenopausal women, making it a candidate for osteoporosis prevention.
  • Endocrine Disruptor Research: The compound is studied for its effects on endocrine systems, contributing to understanding how certain chemicals influence hormonal balance.
  • Pharmaceutical Development: Toremifene citrate serves as a model compound in drug formulation studies, aiding researchers in developing new therapies with improved efficacy and safety profiles.

Citations