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Catalog Number:
38237
CAS Number:
162401-32-3
Roflumilast
Purity:
≥ 98% (HPLC)
Synonym(s):
3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide
Documents
$168.35 /250MG
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Product Information

Roflumilast is a potent phosphodiesterase-4 (PDE4) inhibitor, primarily utilized in the management of chronic obstructive pulmonary disease (COPD). This compound works by reducing inflammation in the airways, thereby improving lung function and overall respiratory health. Its unique mechanism of action makes it particularly beneficial for patients who experience frequent exacerbations, offering a targeted approach to long-term management. Roflumilast is also being explored for potential applications in other inflammatory conditions, showcasing its versatility in therapeutic use.

In research settings, Roflumilast serves as a valuable tool for studying the pathways involved in inflammation and respiratory diseases. Its ability to modulate immune responses positions it as a promising candidate for further investigation in various therapeutic areas. With a favorable safety profile and the potential to enhance the efficacy of other treatments, Roflumilast stands out as a significant advancement in respiratory medicine.

Synonyms
3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide
CAS Number
162401-32-3
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14Cl2F2N2O3
Molecular Weight
403.21
MDL Number
MFCD00938270
PubChem ID
449193
Melting Point
157 - 161 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
General Information
Synonyms
3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide
CAS Number
162401-32-3
Purity
≥ 98% (HPLC)
Molecular Formula
C17H14Cl2F2N2O3
Molecular Weight
403.21
MDL Number
MFCD00938270
PubChem ID
449193
Melting Point
157 - 161 °C
Appearance
White to orange to green powder to crystal
Conditions
Store at < -20 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Roflumilast is widely utilized in research focused on

  • Chronic Obstructive Pulmonary Disease (COPD) Treatment: It is primarily used as a treatment for COPD, helping to reduce inflammation and improve lung function, which is crucial for patients managing this chronic condition.
  • Anti-inflammatory Research: Researchers explore its anti-inflammatory properties, making it valuable in studies aimed at understanding and developing treatments for various inflammatory diseases.
  • Pharmaceutical Development: The compound serves as a model for developing new medications, particularly in the respiratory field, due to its unique mechanism of action as a phosphodiesterase-4 inhibitor.
  • Combination Therapy Studies: It is often investigated in combination with other drugs to enhance therapeutic effects in respiratory diseases, providing insights into more effective treatment regimens.
  • Clinical Trials: Roflumilast is a key subject in clinical trials aimed at assessing its efficacy and safety, contributing to the advancement of respiratory health treatments.

Citations