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Catalog Number:
38236
CAS Number:
85416-73-5
(S)-(+)-Rolipram
Purity:
≥ 98% (HPLC)
Synonym(s):
(S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Documents
$209.61 /10MG
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Product Information

(S)-(+)-Rolipram is a selective phosphodiesterase-4 (PDE4) inhibitor, renowned for its potential therapeutic applications in treating various inflammatory and neurodegenerative conditions. This compound has garnered attention in research for its ability to enhance cognitive function and mood by increasing intracellular levels of cyclic AMP (cAMP). Its unique structure, featuring a cyclopentyloxy group, contributes to its specificity and efficacy, making it a valuable candidate in the development of treatments for disorders such as depression and Alzheimer's disease.

In addition to its neuroprotective properties, (S)-(+)-Rolipram has been explored for its role in modulating immune responses, offering promising avenues for managing chronic inflammatory diseases. Researchers appreciate its relatively low toxicity profile compared to other PDE inhibitors, which enhances its appeal in clinical settings. With ongoing studies, (S)-(+)-Rolipram holds significant potential for advancing therapeutic strategies in both neurological and inflammatory disorders, making it a compound of interest for pharmaceutical development and research.

Synonyms
(S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number
85416-73-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD03093861
PubChem ID
5092
Melting Point
132 - 136 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = 29 - 34 ° (C=0.5 in Methanol)
Conditions
Store at < 0 °C
General Information
Synonyms
(S)-(+)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number
85416-73-5
Purity
≥ 98% (HPLC)
Molecular Formula
C16H21NO3
Molecular Weight
275.35
MDL Number
MFCD03093861
PubChem ID
5092
Melting Point
132 - 136 °C
Appearance
White to almost white powder to crystal
Optical Rotation
[a]D20 = 29 - 34 ° (C=0.5 in Methanol)
Conditions
Store at < 0 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(S)-(+)-Rolipram is widely utilized in research focused on

  • Neuropharmacology: This compound is studied for its potential to enhance cognitive function and memory. Researchers explore its effects on neurodegenerative diseases like Alzheimer’s, where it may help improve synaptic plasticity.
  • Anti-inflammatory Applications: Rolipram acts as a phosphodiesterase inhibitor, which can reduce inflammation. This property is valuable in developing treatments for conditions such as asthma and rheumatoid arthritis.
  • Psychiatric Disorders: The compound is being investigated for its antidepressant effects. Its ability to increase levels of cyclic AMP in the brain may offer new avenues for treating depression and anxiety disorders.
  • Cardiovascular Research: Due to its vasodilatory properties, Rolipram is explored in studies related to heart health, potentially aiding in the treatment of heart failure and hypertension.
  • Drug Development: As a lead compound, it serves as a model for synthesizing new drugs with improved efficacy and safety profiles, particularly in the fields of neurology and psychiatry.

Citations