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Catalog Number:
38196
CAS Number:
219580-11-7
PD 173074
Purity:
≥ 95% (HPLC)
Synonym(s):
1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
Documents
$177.67 /10MG
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Product Information

PD 173074 is a potent and selective inhibitor of the protein kinase B (PKB/Akt) pathway, making it a valuable tool for researchers investigating cancer and other diseases driven by aberrant signaling pathways. This compound is particularly relevant in studies focused on the modulation of cell growth, survival, and metabolism, as it effectively disrupts the PKB signaling cascade. Its unique structure, featuring a pyrido[2,3-d]pyrimidine core, enhances its binding affinity and specificity, setting it apart from other kinase inhibitors.

In practical applications, PD 173074 has shown promise in preclinical models of various cancers, including breast and prostate cancer, where it aids in understanding the role of Akt in tumor progression and resistance to therapy. Researchers can leverage this compound to explore therapeutic strategies that target the Akt pathway, potentially leading to more effective treatments. Its ability to selectively inhibit PKB/Akt makes it an essential addition to the toolkit of any laboratory focused on cancer research or drug development.

Synonyms
1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
CAS Number
219580-11-7
Purity
≥ 95% (HPLC)
Molecular Formula
C28H41N7O3
Molecular Weight
523.68
MDL Number
MFCD08705327
PubChem ID
1401
Melting Point
85 - 87 °C
Appearance
White to yellow to orange powder to crystal
Conditions
Store at 2 - 8 °C
General Information
Synonyms
1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
CAS Number
219580-11-7
Purity
≥ 95% (HPLC)
Molecular Formula
C28H41N7O3
Molecular Weight
523.68
MDL Number
MFCD08705327
PubChem ID
1401
Melting Point
85 - 87 °C
Appearance
White to yellow to orange powder to crystal
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

PD 173074 is widely utilized in research focused on:

  • Oncology Research: This compound is primarily used in cancer research due to its ability to inhibit specific kinases involved in tumor growth, providing a pathway for developing targeted therapies.
  • Neuroscience Studies: Researchers leverage PD 173074 to investigate its effects on neurodegenerative diseases, exploring its potential to modulate pathways that protect neuronal health.
  • Pharmaceutical Development: The compound serves as a valuable lead in the synthesis of new drugs, particularly in the development of treatments for various cancers and neurological disorders.
  • Biochemical Assays: PD 173074 is employed in assays to study cellular signaling pathways, helping scientists understand the mechanisms of disease at a molecular level.
  • Comparative Studies: Its unique properties make it a critical reference compound in studies comparing the efficacy of other kinase inhibitors, aiding in the advancement of targeted therapies.

Citations