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Catalog Number:
37707
CAS Number:
1492-18-8
Calcium folinate
Purity:
95 - 105% (Assay, On anhydrous basis)
Synonym(s):
Folinic acid calcium salt
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Product Information

Calcium folinate, also known as leucovorin or citrovorum factor, is a vital compound widely utilized in the pharmaceutical industry, particularly in cancer therapy and the treatment of folate deficiency. This active form of folic acid plays a crucial role in enhancing the efficacy of certain chemotherapy agents, such as methotrexate, by mitigating their toxic effects on healthy cells. Its ability to support DNA synthesis and repair makes it an essential adjunct in cancer treatment protocols, helping to reduce side effects and improve patient outcomes. Additionally, calcium folinate is employed in managing conditions related to folate deficiency, such as megaloblastic anemia, providing a rapid and effective means of replenishing folate levels in patients.

The unique properties of calcium folinate, including its high solubility and stability, make it an attractive choice for researchers and healthcare professionals. Its application extends beyond oncology, with potential uses in various fields, including pediatrics and obstetrics, where folate supplementation is critical. By choosing calcium folinate, professionals can ensure optimal therapeutic results while minimizing adverse effects, making it a valuable asset in both clinical and research settings.

Synonyms
Folinic acid calcium salt
CAS Number
1492-18-8
Purity
95 - 105% (Assay, On anhydrous basis)
Molecular Formula
C20H21CaN7O7
Molecular Weight
511.51
MDL Number
MFCD00006704
PubChem ID
135408067
Appearance
White or light yellow crystalline powder
Conditions
Store at 2 - 8 °C
General Information
Synonyms
Folinic acid calcium salt
CAS Number
1492-18-8
Purity
95 - 105% (Assay, On anhydrous basis)
Molecular Formula
C20H21CaN7O7
Molecular Weight
511.51
MDL Number
MFCD00006704
PubChem ID
135408067
Appearance
White or light yellow crystalline powder
Conditions
Store at 2 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Calcium folinate is widely utilized in research focused on:

  • Oncology Treatments: It serves as a rescue agent in chemotherapy, particularly for patients receiving methotrexate. By mitigating the drug's toxic effects, it helps improve patient outcomes and reduce side effects.
  • Folic Acid Supplementation: In the medical field, it is used to prevent and treat folate deficiency, especially in pregnant women and individuals with malabsorption issues, ensuring healthy fetal development and overall well-being.
  • Pharmaceutical Formulations: Calcium folinate is incorporated into various drug formulations, enhancing the stability and bioavailability of active ingredients, which is crucial for effective therapeutic outcomes.
  • Research in Biochemistry: It is utilized in laboratory settings to study folate metabolism and its role in cellular processes, providing insights that can lead to new therapeutic strategies.
  • Agricultural Applications: The compound is also explored in agriculture to improve plant growth and nutrient uptake, contributing to sustainable farming practices and increased crop yields.

Citations