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Catalog Number:
32504
CAS Number:
59-42-7
L-Phenylephrine
Grade:
EP
Purity:
99.0 - 100.5% (Assay by titration)
Synonym(s):
(R)-(-)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol, (R)-(-)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol
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Product Information

L-Phenylephrine is a potent sympathomimetic agent widely utilized in the pharmaceutical industry for its vasoconstrictive properties. This compound is primarily recognized for its application as a decongestant in over-the-counter medications, effectively alleviating nasal congestion associated with colds, allergies, and sinusitis. Its mechanism of action involves selective stimulation of alpha-1 adrenergic receptors, leading to vasoconstriction and reduced swelling in nasal passages.

In addition to its use in respiratory treatments, L-Phenylephrine is also employed in ophthalmology as a mydriatic agent, facilitating pupil dilation during eye examinations. Researchers and healthcare professionals appreciate its rapid onset and relatively short duration of action, making it a reliable choice for acute interventions. Furthermore, L-Phenylephrine's safety profile and effectiveness in various formulations, including oral, nasal, and injectable forms, enhance its versatility in clinical applications.

Synonyms
(R)-(-)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol, (R)-(-)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol
CAS Number
59-42-7
Purity
99.0 - 100.5% (Assay by titration)
Grade
EP
Molecular Formula
C9H13NO2
Molecular Weight
167.21
MDL Number
MFCD00044749
PubChem ID
4782
Melting Point
172 - 174 °C
Appearance
White or almost white crystalline powder
Optical Rotation
[a]D20 = -53 to -57 °
Conditions
Store at RT
General Information
Synonyms
(R)-(-)-3-[1-Hydroxy-2-(methylamino)ethyl]phenol, (R)-(-)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol
CAS Number
59-42-7
Purity
99.0 - 100.5% (Assay by titration)
Grade
EP
Molecular Formula
C9H13NO2
Molecular Weight
167.21
MDL Number
MFCD00044749
PubChem ID
4782
Melting Point
172 - 174 °C
Appearance
White or almost white crystalline powder
Optical Rotation
[a]D20 = -53 to -57 °
Conditions
Store at RT
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

L-Phenylephrine is widely utilized in research focused on:

  • Pharmaceuticals: Commonly used as a decongestant in cold and allergy medications, it helps relieve nasal congestion by constricting blood vessels in the nasal passages.
  • Anesthesia: Employed in surgical settings to manage blood pressure during procedures, providing a safer environment for patients undergoing anesthesia.
  • Cardiology: Used in emergency medicine to treat hypotension, especially in critical care situations, ensuring stable blood pressure levels for patients.
  • Ophthalmology: Applied as a mydriatic agent to dilate pupils during eye examinations, facilitating better visibility for eye care professionals.
  • Research Applications: Investigated in studies related to vascular responses and adrenergic receptor activity, contributing to the understanding of cardiovascular health and drug interactions.

Citations