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Catalog Number:
41719
Methyl-PEG12-maleimide
Purity:
≥ 95% (HPLC)
Synonym(s):
mPEG12-Maleimide, 3-Maleimido-N-(2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-yl)propionamide
Documents
$372.86 /25MG
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Product Information

Methyl-PEG12-maleimide is a versatile compound widely utilized in bioconjugation and drug delivery applications. This maleimide derivative features a polyethylene glycol (PEG) chain, which enhances solubility and biocompatibility, making it an ideal choice for researchers and industry professionals working in the fields of pharmaceuticals and biotechnology. Its unique structure allows for selective conjugation to thiol-containing biomolecules, facilitating the development of targeted therapies and diagnostic agents.

In addition to its use in drug delivery systems, Methyl-PEG12-maleimide is also employed in the creation of antibody-drug conjugates (ADCs) and other bioconjugates, where it serves to improve the stability and efficacy of therapeutic agents. The incorporation of PEG not only increases circulation time in the bloodstream but also reduces immunogenicity, providing a significant advantage over non-PEGylated counterparts. With its exceptional properties and practical applications, Methyl-PEG12-maleimide stands out as a valuable tool for advancing research and development in the life sciences.

Synonyms
mPEG12-Maleimide, 3-Maleimido-N-(2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-yl)propionamide
Purity
≥ 95% (HPLC)
Molecular Formula
C32H58N2O15
Molecular Weight
710.82
Appearance
White to orange to green powder to crystal
Conditions
Store at ≤ -10 °C
General Information
Synonyms
mPEG12-Maleimide, 3-Maleimido-N-(2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontan-37-yl)propionamide
Purity
≥ 95% (HPLC)
Molecular Formula
C32H58N2O15
Molecular Weight
710.82
Appearance
White to orange to green powder to crystal
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Methyl-PEG12-maleimide is widely utilized in research focused on:

  • Bioconjugation: This compound is frequently used to attach biomolecules, such as proteins or antibodies, to surfaces or other molecules, enhancing the stability and functionality of the resulting conjugates.
  • Drug Delivery Systems: Its properties allow for the development of advanced drug delivery systems, improving the solubility and bioavailability of therapeutic agents, which is crucial in pharmaceutical applications.
  • Diagnostics: Methyl-PEG12-maleimide is employed in the creation of diagnostic tools, such as biosensors, where it helps in the immobilization of biological recognition elements, leading to more sensitive and specific detection methods.
  • Polymer Chemistry: This compound serves as a building block in the synthesis of functionalized polymers, which can be tailored for specific applications in materials science, including coatings and adhesives.
  • Regenerative Medicine: In tissue engineering, it is used to modify scaffolds, promoting cell adhesion and growth, which is essential for developing effective regenerative therapies.

Citations