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Catalog Number:
39692
CAS Number:
74648-14-9
Di(N-succinimidyl) pimelate
Purity:
≥ 98% (NMR)
Synonym(s):
Bis(2,5-dioxopyrrolidin-1-yl) heptanedioate, Pimelic acid Di(N-succinimidyl) ester, Heptanedioic acid bis2,5-dioxopyrrolidin-1-yl) ester
Documents
$95.84 /250MG
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Product Information

Di(N-succinimidyl) pimelate is a versatile crosslinking agent widely utilized in bioconjugation and protein labeling applications. This compound, also known as bis(2,5-dioxopyrrolidin-1-yl) heptanedioate, features two succinimidyl groups that facilitate the formation of stable amide bonds with primary amines, making it ideal for the conjugation of proteins, peptides, and other biomolecules. Its unique structure allows for efficient crosslinking, enhancing the stability and functionality of the resulting conjugates. Researchers in the fields of biochemistry and molecular biology can leverage this compound for creating targeted drug delivery systems, developing diagnostic assays, and improving the efficacy of vaccines.

The compound's ability to form stable linkages under mild conditions sets it apart from other crosslinkers, providing a significant advantage in maintaining the biological activity of sensitive biomolecules. Its applications extend to the development of antibody-drug conjugates and in the synthesis of complex biomolecular structures, making it a valuable tool for researchers aiming to innovate in therapeutic and diagnostic technologies.

Synonyms
Bis(2,5-dioxopyrrolidin-1-yl) heptanedioate, Pimelic acid Di(N-succinimidyl) ester, Heptanedioic acid bis2,5-dioxopyrrolidin-1-yl) ester
CAS Number
74648-14-9
Purity
≥ 98% (NMR)
Molecular Formula
C15H18N2O8
Molecular Weight
354.32
MDL Number
MFCD01318519
PubChem ID
13650501
Melting Point
124 - 128 °C
Appearance
White to off-white solid
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Bis(2,5-dioxopyrrolidin-1-yl) heptanedioate, Pimelic acid Di(N-succinimidyl) ester, Heptanedioic acid bis2,5-dioxopyrrolidin-1-yl) ester
CAS Number
74648-14-9
Purity
≥ 98% (NMR)
Molecular Formula
C15H18N2O8
Molecular Weight
354.32
MDL Number
MFCD01318519
PubChem ID
13650501
Melting Point
124 - 128 °C
Appearance
White to off-white solid
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Di(N-succinimidyl) pimelate is widely utilized in research focused on:

  • Bioconjugation: This compound serves as a versatile crosslinker in bioconjugation processes, allowing researchers to attach biomolecules like proteins and antibodies to surfaces or other molecules, enhancing the functionality of diagnostic and therapeutic agents.
  • Drug Delivery Systems: It is employed in the development of drug delivery systems, where it helps to create stable linkages between drugs and carriers, improving the efficacy and targeting of pharmaceuticals.
  • Vaccine Development: The compound plays a crucial role in vaccine formulation by facilitating the conjugation of antigens to carrier proteins, which can enhance immune response and stability of the vaccine.
  • Protein Engineering: In protein engineering, it is used to modify proteins for improved stability and activity, allowing for the creation of more effective enzymes and therapeutic proteins.
  • Diagnostic Assays: This chemical is also applied in the development of diagnostic assays, where it helps in the immobilization of biomolecules on solid supports, leading to enhanced sensitivity and specificity in detection methods.

Citations