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Catalog Number:
39657
CAS Number:
955094-26-5
Maleimide-PEG2-NHS ester
Purity:
≥ 95% (HPLC)
Synonym(s):
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate, 13-Maleimido-11-oxo-4,7-dioxa-10-azatridecanoic acidN-succinimidyl ester, 2,5-Doxopyrrolidin-1-yl3-[2-[2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy]ethoxy]propanoate
Documents
$141.41 /10MG
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Product Information

Maleimide-PEG2-NHS ester is a versatile compound widely utilized in bioconjugation and drug delivery applications. This compound features a maleimide group that allows for selective conjugation to thiol-containing biomolecules, making it an essential tool for researchers in the fields of biochemistry and molecular biology. Its polyethylene glycol (PEG) component enhances solubility and biocompatibility, which is crucial for developing therapeutics and diagnostic agents. The NHS ester functionality facilitates the formation of stable amide bonds with amine-containing molecules, providing a straightforward approach to create targeted drug delivery systems or to label proteins and peptides for imaging studies.

This compound is particularly beneficial in the development of antibody-drug conjugates (ADCs) and other targeted therapies, as it allows for precise attachment of cytotoxic agents to antibodies, enhancing the efficacy of cancer treatments while minimizing off-target effects. Additionally, its application in the synthesis of multifunctional biomaterials opens new avenues in tissue engineering and regenerative medicine. With its unique properties, Maleimide-PEG2-NHS ester stands out as a reliable choice for professionals seeking innovative solutions in their research and development projects.

Synonyms
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate, 13-Maleimido-11-oxo-4,7-dioxa-10-azatridecanoic acidN-succinimidyl ester, 2,5-Doxopyrrolidin-1-yl3-[2-[2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy]ethoxy]propanoate
CAS Number
955094-26-5
Purity
≥ 95% (HPLC)
Molecular Formula
C18H23N3O9
Molecular Weight
425.39
MDL Number
MFCD11041137
PubChem ID
51340948
Melting Point
92 °C (Lit.)
Appearance
White to off white crystalline powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate, 13-Maleimido-11-oxo-4,7-dioxa-10-azatridecanoic acidN-succinimidyl ester, 2,5-Doxopyrrolidin-1-yl3-[2-[2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy]ethoxy]propanoate
CAS Number
955094-26-5
Purity
≥ 95% (HPLC)
Molecular Formula
C18H23N3O9
Molecular Weight
425.39
MDL Number
MFCD11041137
PubChem ID
51340948
Melting Point
92 °C (Lit.)
Appearance
White to off white crystalline powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Maleimide-PEG2-NHS ester is widely utilized in research focused on:

  • Bioconjugation: This compound is ideal for attaching biomolecules such as proteins and peptides to surfaces or other biomolecules, enhancing the development of targeted therapies and diagnostics.
  • Drug Delivery Systems: Its ability to form stable conjugates makes it valuable in creating drug delivery systems that improve the solubility and bioavailability of therapeutic agents.
  • Fluorescent Labeling: Researchers use this compound for labeling biomolecules with fluorescent tags, facilitating the study of cellular processes through imaging techniques.
  • Vaccine Development: It plays a crucial role in the formulation of vaccines by enabling the conjugation of antigens to carriers, enhancing immune response and stability.
  • Polymer Chemistry: The compound is used in the synthesis of functionalized polymers, which are essential in creating advanced materials with specific properties for various industrial applications.

Citations