Discover the new Chem-Impex: Where innovation starts with a bond.

Catalog Number:
39669
CAS Number:
955094-26-5
Maleimide-PEG2-NHS ester
Purity:
≥ 98% (HPLC)
Synonym(s):
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate
Documents
$165.65 /50MG
Pack Size Availability Price
Request Bulk Quote
Product Information

Maleimide-PEG2-NHS ester is a versatile compound widely utilized in bioconjugation and drug delivery applications. This compound features a maleimide group that allows for specific and efficient conjugation to thiol-containing biomolecules, making it an excellent choice for researchers looking to create stable linkages in protein labeling and modification. The polyethylene glycol (PEG) component enhances solubility and biocompatibility, which is crucial for therapeutic applications, particularly in the development of targeted drug delivery systems.

In addition to its use in bioconjugation, Maleimide-PEG2-NHS ester is also employed in the synthesis of antibody-drug conjugates (ADCs), where it facilitates the attachment of cytotoxic agents to antibodies, thereby improving the selectivity and efficacy of cancer therapies. Its unique properties, such as the ability to form stable amide bonds and its favorable pharmacokinetic profile, make it a preferred choice among professionals in the pharmaceutical and biotechnology sectors. Researchers can leverage this compound to enhance the performance of their biomolecular constructs, leading to innovative solutions in diagnostics and therapeutics.

Synonyms
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate
CAS Number
955094-26-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H23N3O9
Molecular Weight
425.39
MDL Number
MFCD11041137
PubChem ID
51340948
Melting Point
90 - 94 °C (Lit.)
Appearance
White powder
Conditions
Store at ≤ -10 °C
General Information
Synonyms
Maleimide-PEG2-succinimidyl ester, N-Succinimidyl13-maleimido-11-oxo-4,7-dioxa-10-azatridecanoate
CAS Number
955094-26-5
Purity
≥ 98% (HPLC)
Molecular Formula
C18H23N3O9
Molecular Weight
425.39
MDL Number
MFCD11041137
PubChem ID
51340948
Melting Point
90 - 94 °C (Lit.)
Appearance
White powder
Conditions
Store at ≤ -10 °C
Properties
Additional property information coming soon!
-
Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Maleimide-PEG2-NHS ester is widely utilized in research focused on:

  • Bioconjugation: This compound is essential for attaching biomolecules, such as proteins or antibodies, to surfaces or other molecules, enhancing the development of targeted therapies and diagnostics.
  • Drug Delivery Systems: Its ability to form stable linkages makes it ideal for creating drug delivery vehicles that release therapeutic agents in a controlled manner, improving treatment efficacy.
  • Diagnostic Applications: Utilized in the development of assays and imaging agents, it helps in the detection of diseases by enabling the labeling of specific biomarkers.
  • Polymer Chemistry: This chemical serves as a building block for synthesizing functionalized polymers, which are used in various applications, including tissue engineering and regenerative medicine.
  • Research Tools: It is a valuable reagent in laboratories for creating custom probes and labels, facilitating advanced research in molecular biology and biochemistry.

Citations