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Catalog Number:
35131
CAS Number:
61135-33-9
5-Ethynyl-2'-deoxyuridine (EdU)
Purity:
≥ 99% (HPLC)
Synonym(s):
5-Ethynyl-2'-dU
Documents
$95.00 /25MG
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Product Information

5-Ethynyl-2'-deoxyuridine (EdU) is a synthetic nucleoside analog that plays a crucial role in molecular biology and biochemistry, particularly in the study of DNA synthesis and cell proliferation. This compound is widely recognized for its ability to incorporate into newly synthesized DNA, making it an invaluable tool for researchers investigating cell division, cancer biology, and regenerative medicine. EdU is often used in click chemistry applications, allowing for the efficient labeling of proliferating cells in live tissues, which provides insights into cellular dynamics and the effects of various treatments on cell growth.

The unique properties of EdU, such as its high sensitivity and specificity in detecting DNA synthesis, set it apart from traditional thymidine analogs. Its compatibility with fluorescence microscopy and flow cytometry further enhances its utility in various experimental setups. Researchers can leverage EdU to explore cellular responses to drugs, understand tumor growth mechanisms, and develop targeted therapies. With its broad applicability in both basic and applied research, EdU remains a vital compound for advancing our understanding of cellular processes.

Synonyms
5-Ethynyl-2'-dU
CAS Number
61135-33-9
Purity
≥ 99% (HPLC)
Molecular Formula
C11H12N2O5
Molecular Weight
252.23
MDL Number
MFCD01675687
PubChem ID
122879
Appearance
White solid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
General Information
Synonyms
5-Ethynyl-2'-dU
CAS Number
61135-33-9
Purity
≥ 99% (HPLC)
Molecular Formula
C11H12N2O5
Molecular Weight
252.23
MDL Number
MFCD01675687
PubChem ID
122879
Appearance
White solid
Conditions
Store at -10 °C, desiccate and shipped at ambient temperature
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

5-Ethynyl-2'-deoxyuridine (EdU) is widely utilized in research focused on:

  • Cell Proliferation Studies: EdU is a powerful tool for tracking cell division. Researchers use it to label newly synthesized DNA in proliferating cells, making it invaluable for cancer research and regenerative medicine.
  • Drug Development: In pharmaceutical research, EdU is employed to assess the efficacy of anti-cancer drugs by measuring their impact on cell growth and proliferation, helping to identify promising therapeutic candidates.
  • Stem Cell Research: EdU is used to study stem cell differentiation and proliferation, providing insights into developmental biology and potential applications in tissue engineering and regenerative therapies.
  • In Vivo Imaging: EdU can be incorporated into living organisms, allowing scientists to visualize and quantify cell proliferation in real-time, which is crucial for understanding disease progression and treatment responses.
  • Comparative Studies: EdU offers advantages over traditional labeling methods like BrdU, as it does not require harsh denaturation steps, making it easier to analyze samples while preserving cell integrity.

Citations