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Catalog Number:
05596
CAS Number:
53100-44-0
Boc-L-pyroglutamic acid
Purity:
≥ 97% (HPLC)
Synonym(s):
Boc-L-Pyr-OH, Boc-(S)-2-pyrrolidinone-5-carboxylic acid
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Product Information

Boc-L-pyroglutamic acid is a valuable compound widely utilized in the pharmaceutical and biochemical industries. This amino acid derivative features a tert-butoxycarbonyl (Boc) protecting group, making it an essential building block in peptide synthesis and drug development. Its unique structure allows for enhanced stability and solubility, which are critical for formulating effective therapeutic agents. Researchers often leverage Boc-L-pyroglutamic acid in the synthesis of cyclic peptides and as a precursor for various bioactive compounds, facilitating advancements in medicinal chemistry.

The compound's applications extend to the development of novel drug candidates, particularly in the fields of neuropharmacology and oncology. Its ability to enhance the bioavailability of peptides makes it a preferred choice for researchers aiming to optimize drug formulations. Additionally, Boc-L-pyroglutamic acid serves as a versatile intermediate in organic synthesis, offering significant advantages over similar compounds due to its ease of use and compatibility with various reaction conditions. This makes it an indispensable tool for both academic and industrial chemists seeking to innovate in their respective fields.

Synonyms
Boc-L-Pyr-OH, Boc-(S)-2-pyrrolidinone-5-carboxylic acid
CAS Number
53100-44-0
Purity
≥ 97% (HPLC)
Molecular Formula
C10H15NO5
Molecular Weight
229.24
MDL Number
MFCD00672316
PubChem ID
12883984
Melting Point
117 - 119 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -35 ± 2 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
General Information
Synonyms
Boc-L-Pyr-OH, Boc-(S)-2-pyrrolidinone-5-carboxylic acid
CAS Number
53100-44-0
Purity
≥ 97% (HPLC)
Molecular Formula
C10H15NO5
Molecular Weight
229.24
MDL Number
MFCD00672316
PubChem ID
12883984
Melting Point
117 - 119 °C
Appearance
White to off-white powder
Optical Rotation
[a]D20 = -35 ± 2 º (C=1 in CHCl3)
Conditions
Store at 0 - 8 °C
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

Boc-L-pyroglutamic acid is widely utilized in research focused on:

  • Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without affecting others. This is crucial in developing complex peptides for pharmaceuticals.
  • Drug Development: Its role in medicinal chemistry is significant, particularly in designing compounds that target specific biological pathways. Researchers leverage its structural properties to enhance the efficacy and selectivity of drug candidates.
  • Bioconjugation: Boc-L-pyroglutamic acid is used in bioconjugation processes, where it helps attach biomolecules to drugs or imaging agents, improving their delivery and effectiveness in targeted therapies.
  • Protein Engineering: In the field of protein engineering, this compound aids in modifying proteins to improve their stability and activity, which is essential for developing better therapeutic proteins.
  • Research in Neurobiology: Its derivatives are explored in neurobiology for their potential effects on neurotransmitter systems, providing insights into neurological disorders and paving the way for new treatment strategies.

Citations