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Catalog Number:
40316
CAS Number:
313545-41-4
4-Chloro-2-(trifluoromethyl)phenylboronic acid
Purity:
97 - 105% (Assay by titration)
Synonym(s):
4-Chloro-2-(trifluoromethyl)benzeneboronic acid
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Product Information

4-Chloro-2-(trifluoromethyl)phenylboronic acid is a versatile boronic acid derivative that plays a crucial role in organic synthesis and medicinal chemistry. This compound is particularly valued for its ability to participate in Suzuki-Miyaura cross-coupling reactions, making it an essential building block for the formation of biaryl compounds. Its unique trifluoromethyl group enhances the electronic properties of the molecule, allowing for improved reactivity and selectivity in various chemical transformations. Researchers and industry professionals utilize this compound in the development of pharmaceuticals, agrochemicals, and advanced materials, where precision and efficiency are paramount.

The compound's distinctive features, such as its strong electrophilic character and compatibility with a range of functional groups, make it an ideal candidate for applications in drug discovery and development. Its ability to facilitate the synthesis of complex molecules with high yields and purity sets it apart from other boronic acids. Additionally, its stability under various reaction conditions ensures reliable performance in laboratory and industrial settings. With its broad applicability and significant advantages, 4-Chloro-2-(trifluoromethyl)phenylboronic acid is a valuable asset for any chemist looking to enhance their synthetic capabilities.

Synonyms
4-Chloro-2-(trifluoromethyl)benzeneboronic acid
CAS Number
313545-41-4
Purity
97 - 105% (Assay by titration)
Molecular Formula
C7H5BClF3O2
Molecular Weight
224.37
MDL Number
MFCD04973086
PubChem ID
2763244
Melting Point
182 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
General Information
Synonyms
4-Chloro-2-(trifluoromethyl)benzeneboronic acid
CAS Number
313545-41-4
Purity
97 - 105% (Assay by titration)
Molecular Formula
C7H5BClF3O2
Molecular Weight
224.37
MDL Number
MFCD04973086
PubChem ID
2763244
Melting Point
182 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Chloro-2-(trifluoromethyl)phenylboronic acid is widely utilized in research focused on:

  • Organic Synthesis: This compound serves as a crucial building block in the synthesis of various pharmaceuticals and agrochemicals, allowing for the development of new drugs and crop protection agents.
  • Cross-Coupling Reactions: It plays a significant role in Suzuki-Miyaura coupling reactions, which are essential for forming carbon-carbon bonds in complex organic molecules, streamlining the synthesis process in the pharmaceutical industry.
  • Fluorinated Compounds: The trifluoromethyl group enhances the biological activity of compounds, making it valuable in the design of potent medicinal agents, particularly in oncology and infectious disease research.
  • Material Science: This chemical is used in the development of advanced materials, including polymers and coatings, which benefit from its unique properties, such as increased thermal stability and chemical resistance.
  • Analytical Chemistry: It serves as a reagent in various analytical techniques, aiding in the detection and quantification of other compounds, which is crucial for quality control in pharmaceuticals and environmental monitoring.

Citations