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Catalog Number:
40312
CAS Number:
176976-42-4
4-Chloro-3-(trifluoromethyl)phenylboronic acid
Purity:
97 - 105% (Assay by titration)
Synonym(s):
4-Chloro-3-(trifluoromethyl)benzeneboronic acid
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Product Information

4-Chloro-3-(trifluoromethyl)phenylboronic acid is a versatile compound widely utilized in organic synthesis and medicinal chemistry. This boronic acid derivative is particularly valued for its ability to participate in Suzuki-Miyaura cross-coupling reactions, making it an essential building block in the development of complex organic molecules, including pharmaceuticals and agrochemicals. Its unique trifluoromethyl group enhances lipophilicity and biological activity, which is beneficial for drug design and optimization.

Researchers and industry professionals can leverage this compound in the synthesis of various biologically active compounds, including inhibitors and other therapeutic agents. Its stability and reactivity under mild conditions allow for efficient incorporation into diverse chemical frameworks, facilitating the rapid development of new materials and drug candidates. The compound's distinct properties make it a preferred choice for applications in both academic research and industrial settings, ensuring high yields and purity in synthetic processes.

Synonyms
4-Chloro-3-(trifluoromethyl)benzeneboronic acid
CAS Number
176976-42-4
Purity
97 - 105% (Assay by titration)
Molecular Formula
C7H5BClF3O2
Molecular Weight
224.37
MDL Number
MFCD03094999
PubChem ID
2782671
Melting Point
233 - 236 °C
Appearance
White to off-white crystalline powder
Boiling Point
236 °C (Lit.)
Conditions
Store at RT
General Information
Synonyms
4-Chloro-3-(trifluoromethyl)benzeneboronic acid
CAS Number
176976-42-4
Purity
97 - 105% (Assay by titration)
Molecular Formula
C7H5BClF3O2
Molecular Weight
224.37
MDL Number
MFCD03094999
PubChem ID
2782671
Melting Point
233 - 236 °C
Appearance
White to off-white crystalline powder
Boiling Point
236 °C (Lit.)
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-Chloro-3-(trifluoromethyl)phenylboronic acid is widely utilized in research focused on:

  • Pharmaceutical Development: This compound plays a crucial role in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting cancer and other diseases due to its ability to form stable complexes with biologically relevant molecules.
  • Organic Synthesis: It is commonly used as a reagent in Suzuki coupling reactions, which are essential for creating complex organic molecules. This application is particularly valuable in the production of agrochemicals and fine chemicals.
  • Material Science: The compound is utilized in the development of advanced materials, including polymers and coatings, where its unique properties can enhance durability and performance.
  • Analytical Chemistry: It serves as a key component in various analytical techniques, helping researchers detect and quantify specific substances in complex mixtures, which is vital in environmental monitoring and quality control.
  • Fluorine Chemistry: The trifluoromethyl group in this compound allows for unique reactivity patterns, making it a valuable tool in fluorine chemistry, which is important for creating new materials with specialized properties.

Citations