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Catalog Number:
40301
CAS Number:
313545-72-1
2-Chloro-4-fluorophenylboronic acid
Purity:
97 - 105% (Assay by titration)
Synonym(s):
2-Chloro-4-fluorobenzeneboronic acid
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Product Information

2-Chloro-4-fluorophenylboronic acid is a versatile compound widely utilized in organic synthesis and medicinal chemistry. This boronic acid derivative is particularly valued for its ability to participate in Suzuki-Miyaura cross-coupling reactions, making it an essential building block for the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals. Its unique combination of a chlorine and fluorine substituent enhances its reactivity and selectivity, allowing for the development of targeted compounds with improved efficacy. Researchers have successfully employed this compound in the synthesis of various biologically active molecules, showcasing its potential in drug discovery and development.

In addition to its applications in synthetic chemistry, 2-Chloro-4-fluorophenylboronic acid is also recognized for its role in the development of advanced materials and sensors. Its ability to form stable complexes with diols makes it useful in the design of selective sensors for detecting sugars and other biomolecules. The compound's favorable properties, such as high stability and solubility in organic solvents, further enhance its applicability in diverse research fields. With its broad range of uses and significant advantages over similar compounds, 2-Chloro-4-fluorophenylboronic acid stands out as a valuable tool for researchers and industry professionals alike.

Synonyms
2-Chloro-4-fluorobenzeneboronic acid
CAS Number
313545-72-1
Purity
97 - 105% (Assay by titration)
Molecular Formula
C6H5BClFO2
Molecular Weight
174.36
MDL Number
MFCD02684295
PubChem ID
17750229
Melting Point
237 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
General Information
Synonyms
2-Chloro-4-fluorobenzeneboronic acid
CAS Number
313545-72-1
Purity
97 - 105% (Assay by titration)
Molecular Formula
C6H5BClFO2
Molecular Weight
174.36
MDL Number
MFCD02684295
PubChem ID
17750229
Melting Point
237 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

2-Chloro-4-fluorophenylboronic acid is widely utilized in research focused on:

  • Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting cancer and other diseases.
  • Organic Synthesis: It is employed in Suzuki coupling reactions, which are essential for forming carbon-carbon bonds in organic chemistry, making it valuable for creating complex molecules.
  • Material Science: The compound is used in the development of new materials, including polymers and nanomaterials, enhancing properties such as conductivity and strength.
  • Agricultural Chemistry: It plays a role in the synthesis of agrochemicals, contributing to the development of effective pesticides and herbicides that improve crop yields.
  • Diagnostic Applications: This boronic acid derivative is utilized in the design of sensors for detecting biomolecules, aiding in medical diagnostics and environmental monitoring.

Citations