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Catalog Number:
40289
CAS Number:
352535-96-7
2-Fluoro-5-(trifluoromethyl)phenylboronic acid
Purity:
98 - 105% (Assay by titration)
Synonym(s):
2-Fluoro-5-(trifluoromethyl)benzeneboronic acid
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Product Information

2-Fluoro-5-(trifluoromethyl)phenylboronic acid is a highly versatile compound that plays a crucial role in organic synthesis and medicinal chemistry. This boronic acid derivative is particularly valued for its ability to participate in Suzuki-Miyaura cross-coupling reactions, making it an essential building block in the development of pharmaceuticals and agrochemicals. Its unique trifluoromethyl group enhances its reactivity and selectivity, allowing for the formation of complex molecular architectures that are pivotal in drug discovery and development. Researchers appreciate its stability and compatibility with various reaction conditions, which facilitates its use in diverse applications ranging from the synthesis of biologically active compounds to the creation of advanced materials.

In addition to its synthetic utility, 2-Fluoro-5-(trifluoromethyl)phenylboronic acid has shown promise in the field of diagnostics and sensor technology due to its distinctive electronic properties. Its ability to form stable complexes with various substrates opens up avenues for innovative applications in chemical sensing and detection. With its robust performance and adaptability, this compound stands out as a valuable asset for researchers and industry professionals seeking to enhance their synthetic methodologies and explore new frontiers in chemical research.

Synonyms
2-Fluoro-5-(trifluoromethyl)benzeneboronic acid
CAS Number
352535-96-7
Purity
98 - 105% (Assay by titration)
Molecular Formula
C7H5BF4O2
Molecular Weight
207.92
MDL Number
MFCD03701538
PubChem ID
2763301
Melting Point
109 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
General Information
Synonyms
2-Fluoro-5-(trifluoromethyl)benzeneboronic acid
CAS Number
352535-96-7
Purity
98 - 105% (Assay by titration)
Molecular Formula
C7H5BF4O2
Molecular Weight
207.92
MDL Number
MFCD03701538
PubChem ID
2763301
Melting Point
109 °C (Lit.)
Appearance
White to off-white crystalline powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

2-Fluoro-5-(trifluoromethyl)phenylboronic acid is widely utilized in research focused on:

  • Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs targeting cancer and other diseases due to its ability to form stable complexes with biological targets.
  • Organic Synthesis: It is employed in cross-coupling reactions, such as Suzuki-Miyaura coupling, which allows for the formation of carbon-carbon bonds, essential for creating complex organic molecules.
  • Material Science: The compound is used in the development of advanced materials, including polymers and coatings, where its unique properties enhance durability and chemical resistance.
  • Fluorinated Compounds: Its fluorine content makes it valuable in synthesizing fluorinated compounds, which are often more stable and lipophilic, improving their bioavailability in medicinal chemistry.
  • Analytical Chemistry: This boronic acid derivative is useful in sensor technology, particularly in the detection of sugars and other biomolecules, providing a reliable method for monitoring biological processes.

Citations