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Catalog Number:
31436
CAS Number:
128796-39-4
4-(Trifluoromethyl)phenylboronic acid
Purity:
≥ 99% (HPLC)
Synonym(s):
4-(Trifluoromethyl)benzeneboronic acid
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Product Information

4-(Trifluoromethyl)phenylboronic acid is a versatile compound widely utilized in organic synthesis and medicinal chemistry. This boronic acid derivative is recognized for its unique trifluoromethyl group, which enhances its reactivity and selectivity in cross-coupling reactions, particularly in the formation of carbon-carbon bonds. Its applications extend to the development of pharmaceuticals, agrochemicals, and advanced materials, making it a valuable tool for researchers and industry professionals alike. The compound's ability to act as a key intermediate in the synthesis of biologically active molecules underscores its importance in drug discovery and development.

In addition to its synthetic utility, 4-(Trifluoromethyl)phenylboronic acid exhibits notable advantages over similar compounds, such as improved solubility and stability under various conditions. This makes it an ideal candidate for applications in high-throughput screening and other research methodologies. Its unique properties not only facilitate the creation of complex molecular architectures but also contribute to the efficiency of chemical processes, ultimately leading to innovative solutions in various fields.

Synonyms
4-(Trifluoromethyl)benzeneboronic acid
CAS Number
128796-39-4
Purity
≥ 99% (HPLC)
Molecular Formula
C7H6BF3O2
Molecular Weight
189.93
MDL Number
MFCD00151855
PubChem ID
2734389
Melting Point
245 - 256 ?C (Lit.)
Appearance
White to off-white powder
Conditions
Store at RT
General Information
Synonyms
4-(Trifluoromethyl)benzeneboronic acid
CAS Number
128796-39-4
Purity
≥ 99% (HPLC)
Molecular Formula
C7H6BF3O2
Molecular Weight
189.93
MDL Number
MFCD00151855
PubChem ID
2734389
Melting Point
245 - 256 ?C (Lit.)
Appearance
White to off-white powder
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

4-(Trifluoromethyl)phenylboronic acid is widely utilized in research focused on:

  • Organic Synthesis: This compound serves as a key building block in the synthesis of various organic molecules, particularly in the development of pharmaceuticals and agrochemicals, due to its ability to form stable boronate esters.
  • Cross-Coupling Reactions: It is extensively used in Suzuki-Miyaura coupling reactions, which are crucial for creating complex organic structures. This application is particularly valuable in the production of advanced materials and fine chemicals.
  • Fluorinated Compounds: The trifluoromethyl group enhances the biological activity and metabolic stability of compounds, making it beneficial in drug design and development, especially in the pharmaceutical industry.
  • Analytical Chemistry: It is employed in the development of sensors and analytical methods for detecting various analytes, leveraging its unique chemical properties to improve sensitivity and selectivity.
  • Material Science: This chemical is utilized in the formulation of advanced materials, including polymers and coatings, where its properties can enhance performance characteristics like thermal stability and chemical resistance.

Citations