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Catalog Number:
41174
CAS Number:
99646-28-3
(R)-(+)-TolBINAP
Purity:
≥ 99% (Chiral purity)
Synonym(s):
(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
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Product Information

(R)-(+)-TolBINAP is a highly regarded chiral ligand widely utilized in asymmetric synthesis and catalysis. This compound is particularly valued for its ability to facilitate enantioselective reactions, making it an essential tool for researchers in the fields of organic chemistry and pharmaceuticals. Its unique structure, featuring a naphthalene backbone and bis(4-methylphenyl)phosphane groups, enhances its reactivity and selectivity in various catalytic processes.

In practical applications, (R)-(+)-TolBINAP has been successfully employed in the synthesis of complex molecules, including pharmaceuticals and agrochemicals, where high enantiomeric purity is crucial. Its effectiveness in catalyzing reactions such as hydrogenation and cross-coupling has made it a preferred choice among chemists seeking to optimize yields and reduce waste. The compound's robust performance in diverse reaction conditions further underscores its versatility and reliability, making it an indispensable asset for both academic research and industrial applications.

Synonyms
(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
CAS Number
99646-28-3
Purity
≥ 99% (Chiral purity)
Molecular Formula
C48H40P2
Molecular Weight
678.8
MDL Number
MFCD01311709
PubChem ID
4189906
Melting Point
258 °C (Lit.)
Appearance
White to off-white crystal
Conditions
Store at RT
General Information
Synonyms
(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl
CAS Number
99646-28-3
Purity
≥ 99% (Chiral purity)
Molecular Formula
C48H40P2
Molecular Weight
678.8
MDL Number
MFCD01311709
PubChem ID
4189906
Melting Point
258 °C (Lit.)
Appearance
White to off-white crystal
Conditions
Store at RT
Properties
Additional property information coming soon!
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Safety and Regulations
Hazmat
No
Antibiotic
No
DEA-regulated
No
Warnings
-
Applications

(R)-(+)-TolBINAP is widely utilized in research focused on:

  • Asymmetric Catalysis: This compound serves as a chiral ligand in various catalytic reactions, enabling the synthesis of enantiomerically pure compounds, which is crucial in pharmaceuticals.
  • Pharmaceutical Development: Its ability to facilitate selective reactions makes it valuable in the development of new drugs, particularly in creating complex organic molecules with specific stereochemistry.
  • Material Science: (R)-(+)-TolBINAP is used in the design of advanced materials, including polymers and nanomaterials, where precise molecular arrangement is essential for desired properties.
  • Organic Synthesis: Researchers leverage this compound to enhance reaction efficiency and yield in organic synthesis, making it a preferred choice for chemists looking to optimize their processes.
  • Environmental Chemistry: Its applications extend to green chemistry initiatives, where it aids in developing more sustainable and less hazardous chemical processes.

Citations